拼凑各个部分。
Assembling the pieces.
作者信息
Thiele Dennis J, Gitlin Jonathan D
机构信息
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Research Drive, LSRC C351, Durham, North Carolina 27710, USA.
出版信息
Nat Chem Biol. 2008 Mar;4(3):145-7. doi: 10.1038/nchembio0308-145.
Abstract
Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.
摘要
过渡金属在特定蛋白质中作为辅因子发挥作用，催化电子交换反应、结合底物并稳定蛋白质结构。对人类疾病和模式生物的研究已经明确了金属摄取、运输和排泄的许多分子细节。当前的挑战是将这些细节整合到生物体和生态系统中金属含量、形态、定位和利用的系统观点中。
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