Must Aviva, Bandini Linda G, Tybor David J, Janssen Ian, Ross Robert, Dietz William H
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA, USA.
Int J Pediatr Obes. 2008;3 Suppl 1(Suppl 1):28-36. doi: 10.1080/17477160801896739.
To characterize visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT) deposition in girls over the pubertal period and to assess the influence of behavioral risk factors on their deposition.
In total, 41 subjects of mean age of 13.5 years (standard deviation, SD=0.9) were assessed at menarche. At 4 years after menarche, follow-up data were available for 24 of these subjects.
VAT and SAAT were measured by magnetic resonance imaging (MRI) and total body fat by isotopic dilution of (18)O water at menarche and 4 years after menarche in a subset of subjects enrolled in a larger study of growth and development. Smoking, alcohol use, and physical activity were assessed by self-report at both time points. Smoking, alcohol use, and physical activity at 4 years after menarche were assessed in relation to concurrent VAT and SAAT, and to the 4-year change in VAT and SAAT.
Smoking and alcohol use at 4 years after menarche was associated with the change in VAT over the 4-year period, before (p<0.03 and p<0.02, respectively), and after adjustment for total body fat (p<0.01 and p<0.02, respectively).
In addition to the established health risks, smoking and drinking, even at low levels, appear to be associated with increased VAT deposition in adolescent females.
描述青春期女孩内脏脂肪组织（VAT）和腹部皮下脂肪组织（SAAT）的沉积情况，并评估行为风险因素对其沉积的影响。
共有41名平均年龄为13.5岁（标准差SD = 0.9）的受试者在月经初潮时接受评估。月经初潮4年后，其中24名受试者有随访数据。
在一项关于生长发育的大型研究中，对部分受试者在月经初潮时和月经初潮4年后通过磁共振成像（MRI）测量VAT和SAAT，并通过（18）O水的同位素稀释法测量全身脂肪。在两个时间点均通过自我报告评估吸烟、饮酒和身体活动情况。对月经初潮4年后的吸烟、饮酒和身体活动情况与同期的VAT和SAAT以及VAT和SAAT的4年变化进行评估。
月经初潮4年后的吸烟和饮酒与4年期间VAT的变化相关，在调整全身脂肪之前（分别为p<0.03和p<0.02）以及调整后（分别为p<0.01和p<0.02）。
除了已确定的健康风险外，吸烟和饮酒，即使是低水平，似乎也与青春期女性VAT沉积增加有关。
