Wärnberg Julia, Nova Esther, Moreno Luis A, Romeo Javier, Mesana Maria I, Ruiz Jonatan R, Ortega Francisco B, Sjöström Michael, Bueno Manuel, Marcos Ascensión
Immunonutrition Group, Department of Metabolism and Nutrition, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Am J Clin Nutr. 2006 Sep;84(3):505-12. doi: 10.1093/ajcn/84.3.505.
In adults, obesity is characterized by a state of chronic low-grade inflammation accompanied by moderately high concentrations of acute phase inflammatory proteins. Recent results regarding C-reactive protein (CRP) point to a similar status in adolescents; however, studies of associations of the serum inflammatory proteins CRP, ceruloplasmin, and complement factors C3 and C4 with body fat distribution remain scarce.
We aimed to establish the possible relations of serum inflammatory proteins with body fat estimates and body fat distribution in an apparently healthy adolescent population.
This report included 472 adolescents (248 males and 224 females) aged 13-18.5 y who were recruited from the Spanish cross-sectional multicenter AVENA Study for whom anthropometric and immunologic data were complete. The concentrations of the serum proteins and the in vitro production of cytokines (interleukin 6 and tumor necrosis factor alpha) by isolated and stimulated white blood cells were measured. Relations with anthropometric measurements were explored by using simple and partial correlations.
CRP, C3, and C4 were correlated with central obesity (as measured by waist circumference) and total body fat in both sexes (P < 0.01) and with ceruloplasmin in females only. After further adjustment for BMI, C3 remained independently associated with central obesity (P < 0.05). Production of the cytokines by white blood cells did not seem to be affected by an excess of body fat.
Total body fat seems to be associated with a chronic low-grade systemic inflammation in apparently healthy adolescents. Central obesity is independently associated with C3 concentrations, which makes this marker especially interesting for further studies of obesity-related diseases.
在成年人中，肥胖的特征是处于慢性低度炎症状态，并伴有急性期炎症蛋白浓度适度升高。最近关于C反应蛋白（CRP）的研究结果表明青少年也有类似情况；然而，关于血清炎症蛋白CRP、铜蓝蛋白以及补体因子C3和C4与体脂分布之间关联的研究仍然很少。
我们旨在确定在明显健康的青少年人群中，血清炎症蛋白与体脂估计值和体脂分布之间的可能关系。
本报告纳入了472名年龄在13至18.5岁之间的青少年（248名男性和224名女性），他们来自西班牙多中心横断面AVENA研究，其人体测量和免疫学数据完整。测量了血清蛋白浓度以及分离和刺激的白细胞产生细胞因子（白细胞介素6和肿瘤坏死因子α）的体外产量。通过简单和偏相关分析探讨了与人体测量指标的关系。
CRP、C3和C4与两性的中心性肥胖（通过腰围测量）和全身脂肪相关（P<0.01），仅女性与铜蓝蛋白相关。在进一步调整体重指数后，C3仍与中心性肥胖独立相关（P<0.05）。白细胞产生细胞因子的情况似乎不受体脂过多的影响。
在明显健康的青少年中，全身脂肪似乎与慢性低度全身炎症有关。中心性肥胖与C3浓度独立相关，这使得该标志物在肥胖相关疾病的进一步研究中特别有意义。
