Dostert Catherine, Meylan Etienne, Tschopp Jürg
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
Adv Drug Deliv Rev. 2008 Apr 29;60(7):830-40. doi: 10.1016/j.addr.2007.12.003. Epub 2007 Dec 31.
The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail. More recently, cytoplasmic sensors were identified, which are capable of detecting not only microbial, but also self molecules. Importantly, while such receptors trigger crucial host responses to microbial insult, over-activity of some of them has been linked to autoinflammatory disorders, hence demonstrating the importance of tightly regulating their actions over time and space. Here, we provide an overview of recent findings covering this area of innate and inflammatory responses that originate from the cytoplasm.
过去十年，天然免疫领域的研究成果丰硕：跨膜Toll样受体（TLRs）被发现是保护宿主抵御微生物攻击的卫士，并且对新出现的信号通路进行了详细表征。最近，又鉴定出了细胞质传感器，它们不仅能够检测微生物，还能检测自身分子。重要的是，虽然这类受体可触发宿主对微生物侵害的关键反应，但其中一些受体的过度激活与自身炎症性疾病有关，这表明在时间和空间上严格调控其作用的重要性。在此，我们概述了涵盖源自细胞质的天然免疫和炎症反应这一领域的最新研究发现。
