Cardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Cardiovascular Research Institute, University Hospitals, Case Western Reserve University, Cleveland, OH, 44106, USA.
Redox Biol. 2020 Jul;34:101545. doi: 10.1016/j.redox.2020.101545. Epub 2020 May 23.
Ambient air pollution is a leading environmental cause of morbidity and mortality globally with most of the outcomes of cardiovascular origin. While numerous mechanisms are proposed to explain the link between air pollutants and cardiovascular events, the evidence supports a role for oxidative stress as a critical intermediary pathway in the transduction of systemic responses in the cardiovascular system. Indeed, alterations in vascular function are a critical step in the development of cardiometabolic disorders such as hypertension, diabetes, and atherosclerosis. This review will provide an overview of the impact of particulate and gaseous pollutants on oxidative stress from human and animal studies published in the last five years. We discuss current gaps in knowledge and evidence to date implicating the role of oxidative stress with an emphasis on inhalational exposures. We conclude with the identification of gaps, and an exhortation for further studies to elucidate the impact of oxidative stress in air pollution mediated effects.
大气污染是全球发病率和死亡率的主要环境原因，其中大部分与心血管疾病有关。虽然提出了许多机制来解释空气污染物与心血管事件之间的联系，但有证据表明氧化应激作为心血管系统中全身反应转导的关键中间途径发挥作用。事实上，血管功能的改变是高血压、糖尿病和动脉粥样硬化等代谢紊乱发展的关键步骤。本综述将概述过去五年中人类和动物研究中颗粒物质和气体污染物对氧化应激的影响。我们讨论了目前在知识和证据方面的差距，这些差距表明氧化应激的作用，并强调了吸入暴露的作用。最后，我们确定了差距，并呼吁进一步研究阐明氧化应激在空气污染介导的效应中的影响。
