Chi O Z, Sommer W, Jasaitis D
Department of Anesthesia, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School-Robert Wood Johnson University Hospital, New Brunswick 08903.
Can J Anaesth. 1991 Apr;38(3):275-80. doi: 10.1007/BF03007614.
The purpose of this study was to examine the relationship of continuous sufentanil infusion (0.71 micrograms.kg-1.min-1 for 14 min) and the response of the power spectrum of the electroencephalogram (EEG) performed during the induction of anaesthesia in 12 patients undergoing CABG surgery. Data were collected at various times including the preinduction period, every minute during the infusion period (minute 0 to 14), and 15, 20 and 25 min after the start of the infusion (1, 6 and 11 min respectively after completion of the infusion). Within three minutes of the sufentanil infusion, the total power and the relative power of delta increased to near maximum, while the 95% spectral edge and the mean frequency decreased markedly. In spite of the continued infusion of sufentanil, there were very little further changes in the EEG activity. This ceiling effect for the EEG changes appear to coincide with the failure to respond to verbal command. We conclude that the power spectrum of the EEG failed to respond to increasing doses of sufentanil during its infusion after the rapid initial changes.
本研究的目的是探讨持续输注舒芬太尼（0.71微克·千克⁻¹·分钟⁻¹，持续14分钟）与12例接受冠状动脉旁路移植术（CABG）手术患者麻醉诱导期间脑电图（EEG）功率谱反应之间的关系。在多个时间点收集数据，包括诱导前阶段、输注期间的每分钟（第0至14分钟）以及输注开始后15、20和25分钟（分别在输注完成后1、6和11分钟）。在舒芬太尼输注的三分钟内，δ波的总功率和相对功率增加至接近最大值，而95%频谱边缘和平均频率显著降低。尽管持续输注舒芬太尼，但EEG活动几乎没有进一步变化。EEG变化的这种天花板效应似乎与对言语指令无反应相吻合。我们得出结论，在最初的快速变化之后，EEG功率谱在舒芬太尼输注期间对增加剂量的舒芬太尼无反应。
