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对主要为老年患者采用椎板自体骨移植和β-磷酸三钙进行的非器械辅助腰椎后外侧融合术的分析。

An analysis of noninstrumented posterolateral lumbar fusions performed in predominantly geriatric patients using lamina autograft and beta tricalcium phosphate.

作者信息

Epstein Nancy E

机构信息

Neurological Surgery, The Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Spine J. 2008 Nov-Dec;8(6):882-7. doi: 10.1016/j.spinee.2007.11.005. Epub 2008 Feb 14.

Abstract

BACKGROUND CONTEXT

The artificial bone-volume expander, beta tricalcium phosphate (B-TCP, Vitoss, OrthoVita, Malvern, PA), is increasingly used to supplement autograft in posterolateral lumbar fusions.

PURPOSE

To determine fusion rates/outcomes using B-TCP/autograft.

STUDY DESIGN/SETTING: Fusion rates and outcomes were assessed for 60 predominantly geriatric patients undergoing multilevel lumbar laminectomies and 1- to 2-level noninstrumented fusions using B-TCP/autograft.

PATIENT SAMPLE

Patients on average were 70 years old.

OUTCOME MEASURES

Odom's criteria and Short-Form 36 (SF-36) outcomes were studied 2 years postoperatively.

METHODS

Sixty patients underwent an average of 5.4-level laminectomies with 1- to 2-level noninstrumented fusions. Based on dynamic X-ray/magnetic resonance/computed tomography (CT) studies, laminectomies addressed multilevel stenosis (60 patients), ossification of the yellow ligament (46 patients), disc herniations (20 patients), or synovial cysts (8 patients), and fusions addressed degenerative spondylolisthesis (48 patients), spondylolisthesis/lysis (2 patients), or degenerative scoliosis (10 patients). The fusion mass on each side contained half of all harvested autograft combined with one to 1.5 strips of B-TCP (saturated in 10cc of bone marrow aspirate/strip). Fusion rates were documented by two independent neuroradiologists using both dynamic X-rays, and thin-cut CT (2-dimensional/3-dimensional CT) studies obtained up to 2 years postoperatively. Odom's criteria and SF-36 outcomes were assessed over the same interval.

RESULTS

Pseudarthrosis was documented in nine (15%) patients. Two years postoperatively, Odom's criteria revealed 28 excellent, 23 good, 5 fair, and 4 poor results, whereas SF-36 data revealed improvement on 6 of 8 Health Scales in all patients.

CONCLUSIONS

A 15% pseudarthrosis rate followed multilevel laminectomy and 1- to 2-level noninstrumented posterolateral fusion using lamina autograft/B-TCP.

摘要

背景

人工骨量扩张剂β-磷酸三钙(B-TCP,Vitoss,OrthoVita,宾夕法尼亚州马尔文)越来越多地用于补充腰椎后路融合术中的自体骨移植。

目的

确定使用B-TCP/自体骨移植的融合率/结果。

研究设计/地点:评估了60例主要为老年患者的融合率和结果,这些患者接受了多节段腰椎椎板切除术以及使用B-TCP/自体骨移植的1至2节段非内固定融合术。

患者样本

患者平均年龄为70岁。

观察指标

术后2年采用奥多姆标准和简短健康调查问卷(SF-36)评估结果。

方法

60例患者平均接受了5.4节段的椎板切除术及1至2节段的非内固定融合术。根据动态X线、磁共振成像/计算机断层扫描(CT)研究,椎板切除术用于治疗多节段狭窄(60例患者)、黄韧带骨化(46例患者)、椎间盘突出(20例患者)或滑膜囊肿(8例患者),融合术用于治疗退行性椎体滑脱(48例患者)、椎体滑脱/峡部裂(2例患者)或退行性脊柱侧凸(10例患者)。每侧的融合块包含所有采集的自体骨的一半,以及1至1.5条B-TCP(每条在10cc骨髓抽吸物中浸泡)。两名独立的神经放射科医生通过动态X线以及术后长达2年的薄层CT(二维/三维CT)研究记录融合率。在相同时间段内评估奥多姆标准和SF-36结果。

结果

9例(15%)患者出现假关节形成。术后2年,奥多姆标准显示28例结果为优,23例为良,5例为可,4例为差,而SF-36数据显示所有患者的8个健康量表中有6个有所改善。

结论

多节段椎板切除术及使用椎板自体骨/B-TCP进行1至2节段非内固定后外侧融合术后假关节形成率为15%。

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