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使用椎板自体骨移植和纳米羟基磷灰石/骨髓抽吸物的高位腰椎非器械融合率

High lumbar noninstrumented fusion rates using lamina autograft and Nanoss/bone marrow aspirate.

作者信息

Epstein Nancy E

机构信息

Chief of Neurosurgical Spine/Education, NYU Winthrop Hospital, Mineola, New York, USA.

出版信息

Surg Neurol Int. 2017 Jul 20;8:153. doi: 10.4103/sni.sni_248_17. eCollection 2017.

DOI:10.4103/sni.sni_248_17
PMID:28808602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5535563/
Abstract

BACKGROUND

Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass.

METHODS

In 59 patients, we prospectively analyzed the fusion rates following multilevel laminectomies/noninstrumented fusions using lamina autograft and the bone graft expander Nanoss (RTI Surgical Alachua, FL, and USA) with autogenous bone marrow aspirate (BMA). Patients averaged 66.1 years of age; many exhibited marked osteoporosis (48 patients) and obesity (13 of 27 morbidly obese). Magnetic resonance (MR) and computed tomography (CT) studies documented stenosis/ossified yellow ligament (OYL) and degenerative spondylolisthesis (51 patients)/lysis (2 patients), synovial cysts (32 patients), and disc herniations (10 of 21 far lateral). Patients were followed remove up for an average of 3.12 years.

RESULTS

Average 4.0 level laminectomies/1.2 level noninstrumented fusions utilized lamina autograft and Nanoss/BMA. Both X-ray/CT studies performed an average of 4.9 months postoperatively documented a 97% fusion rate (57 of 59 patients). Two patients with severe osteoporosis, morbid obesity, and smoking histories exhibited pseudarthroses; neither was sufficiently symptomatic to require secondary surgery.

CONCLUSIONS

Fifty-nine patients with multilevel lumbar stenosis/OYL and other pathology underwent multilevel lumbar laminectomies/noninstrumented fusions using lamina autograft and Nanoss/BMA. Both dynamic X-ray/CT studies confirmed a 97% fusion rate an average of 4.9 months postoperatively. Nanoss/BMA contributed to a high posterolateral lumbar non instrumented fusion rate without complciations.

摘要

背景

患有明显骨质疏松症和/或肥胖症/病态肥胖症以及严重多节段腰椎管狭窄症和其他病变的患者，通常会接受多节段椎板切除术并进行非器械辅助的后外侧融合术（PLF）。其他病变可能包括退变性椎体滑脱/椎弓根峡部裂、椎间孔/远外侧椎间盘以及/或需要更广泛关节突切除的滑膜囊肿的组合。目前，脊柱外科医生经常使用骨移植扩张器来补充在椎板切除/减压过程中获取的用于PLF植骨块的椎板自体骨。

方法

在59例患者中，我们前瞻性分析了使用椎板自体骨以及骨移植扩张器Nanoss（美国佛罗里达州阿拉楚阿市RTI Surgical公司生产）和自体骨髓抽吸物（BMA）进行多节段椎板切除/非器械辅助融合术后的融合率。患者平均年龄为66.1岁；许多患者表现出明显的骨质疏松症（48例）和肥胖症（27例病态肥胖患者中的13例）。磁共振成像（MR）和计算机断层扫描（CT）研究记录了椎管狭窄/黄韧带骨化（OYL）以及退变性椎体滑脱（51例患者）/椎弓根峡部裂（2例患者）、滑膜囊肿（32例患者）和椎间盘突出（21例远外侧患者中的10例）。对患者进行了平均3.12年的随访。

结果

平均进行了4.0节段的椎板切除术/1.2节段的非器械辅助融合术，使用了椎板自体骨以及Nanoss/BMA。术后平均4.9个月进行的X线/CT研究均显示融合率为97%（共59例患者中的57例）。两名患有严重骨质疏松症、病态肥胖症且有吸烟史的患者出现了假关节；两人均无足够症状需要二次手术。

结论

59例患有多节段腰椎管狭窄/OYL和其他病变的患者接受了使用椎板自体骨以及Nanoss/BMA的多节段腰椎椎板切除术/非器械辅助融合术。动态X线/CT研究均证实术后平均4.9个月时融合率为97%。Nanoss/BMA有助于实现较高的腰椎后外侧非器械辅助融合率且无并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c9/5535563/51e774242253/SNI-8-153-g008.jpg
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本文引用的文献

1
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2
Comparison of Silicate-Substituted Calcium Phosphate (Actifuse) with Recombinant Human Bone Morphogenetic Protein-2 (Infuse) in Posterolateral Instrumented Lumbar Fusion.硅酸钙取代的磷酸钙（Actifuse）与重组人骨形态发生蛋白-2（Infuse）在后外侧器械化腰椎融合中的比较。
Global Spine J. 2015 Dec;5(6):471-8. doi: 10.1055/s-0035-1566230.
3
Posterolateral fusion in acute traumatic thoracolumbar fractures: a comparison of demineralized bone matrix and autologous bone graft.
J Mater Sci Mater Med. 2020 Mar 2;31(3):27. doi: 10.1007/s10856-020-06364-y.
4
Case presentation and short perspective on management of foraminal/far lateral discs and stenosis.椎间孔/极外侧椎间盘突出症及狭窄症的病例介绍与治疗短评
Surg Neurol Int. 2018 Apr 23;9:87. doi: 10.4103/sni.sni_66_18. eCollection 2018.
急性创伤性胸腰椎骨折的后外侧融合术：脱矿骨基质与自体骨移植的比较
Acta Chir Orthop Traumatol Cech. 2015;82(2):119-25.
4
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Surg Neurol Int. 2015 Jun 25;6(Suppl 10):S318-22. doi: 10.4103/2152-7806.159380. eCollection 2015.
5
Bone graft and bone graft substitutes in spine surgery: current concepts and controversies.脊柱外科中的骨移植和骨移植替代物：当前的概念和争议。
J Am Acad Orthop Surg. 2013 Jan;21(1):51-60. doi: 10.5435/JAAOS-21-01-51.
6
Silicate-substituted calcium phosphate as a bone graft substitute in surgery for adolescent idiopathic scoliosis.硅取代钙磷作为青少年特发性脊柱侧凸手术中的骨移植替代物。
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7
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8
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Spine J. 2008 Nov-Dec;8(6):882-7. doi: 10.1016/j.spinee.2007.11.005. Epub 2008 Feb 14.
9
Efficacy of different bone volume expanders for augmenting lumbar fusions.不同骨量扩张器用于增强腰椎融合术的疗效
Surg Neurol. 2008 Jan;69(1):16-9; discussion 19. doi: 10.1016/j.surneu.2007.03.021.
10
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J Spinal Disord Tech. 2006 Aug;19(6):424-9. doi: 10.1097/00024720-200608000-00009.