迈向预测性、预防性和个性化小儿外科。

Towards predictive, preventive, and personalized paediatric surgery.

作者信息

Tam Paul K H

机构信息

Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong.

出版信息

J Pediatr Surg. 2008 Feb;43(2):267-73. doi: 10.1016/j.jpedsurg.2007.10.012.

DOI:10.1016/j.jpedsurg.2007.10.012

PMID:18280272

Abstract

Future medicine will be revolutionized by genomic and stem cell research, becoming predictive, preventive, and personalized. Despite the smallness of the specialty, paediatric surgery is well placed to play a determining role in this exciting development. First, paediatric surgeons are innovators and leaders. Second, paediatric surgery thrives on the multidisciplinary approach. Third, congenital anomalies provide genetic models for studies of complex diseases. Fourth, morphogenesis underpins basic understanding in development, ageing, cancer, and immunology. The next generation paediatric surgeons must seize the opportunities in large-scale biology research to develop the best future treatment for their patients.

摘要

未来医学将因基因组学和干细胞研究而发生变革，变得具有预测性、预防性和个性化。尽管小儿外科专业规模较小，但在这一激动人心的发展中，小儿外科处于有利地位，能发挥决定性作用。其一，小儿外科医生是创新者和领导者。其二，小儿外科依靠多学科方法蓬勃发展。其三，先天性异常为复杂疾病研究提供了遗传模型。其四，形态发生是发育、衰老、癌症和免疫学基础理解的支撑。下一代小儿外科医生必须抓住大规模生物学研究中的机遇，为患者开发出最佳的未来治疗方法。