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洗必泰凝胶与洗必泰漱口水在减少下颌第三磨牙手术中牙槽骨炎方面的有效性比较

Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery.

作者信息

Hita-Iglesias Pilar, Torres-Lagares Daniel, Flores-Ruiz Rafael, Magallanes-Abad Natale, Basallote-Gonzalez Marta, Gutierrez-Perez Jose-Luis

机构信息

Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109-0018, USA.

出版信息

J Oral Maxillofac Surg. 2008 Mar;66(3):441-5. doi: 10.1016/j.joms.2007.06.641.

Abstract

PURPOSE

Chlorhexidine is an antimicrobial agent used in the prevention of postextraction alveolar osteitis, tooth decay, and periodontal diseases. There are various forms of chlorhexidine application. The most extensively studied is one that uses the rinse as the form of application. Recently, a bioadhesive gel form has become available. Its main advantage is that it prolongs the bioavailability of chlorhexidine in the application area. The purpose of this study was to compare the effectiveness of chlorhexidine gel versus a chlorhexidine rinse in reducing postoperative alveolar osteitis after the extraction of mandibular third molars.

MATERIALS AND METHODS

The experimental or gel group (n = 41) applied the bioadhesive 0.2% chlorhexidine gel to the wound during the first postoperative week and a control or rinse group (n = 32) used a 0.12% chlorhexidine rinse during the first week postextraction.

RESULTS

We observed a 70% decrease in postoperative alveolar osteitis in the gel group (P = .040). The rinse group had 25% incidence postoperative alveolar osteitis, while the gel group had 7.5%.

CONCLUSIONS

It was concluded that the topical application of bioadhesive chlorhexidine gel to the surgical wound during the postoperative week may decrease the incidence of alveolar osteitis after extraction of the mandibular third molars.

摘要

目的

洗必泰是一种用于预防拔牙后牙槽骨炎、龋齿和牙周疾病的抗菌剂。洗必泰有多种应用形式。研究最广泛的是使用漱口水作为应用形式。最近,一种生物粘附凝胶形式已上市。其主要优点是它能延长洗必泰在应用部位的生物利用度。本研究的目的是比较洗必泰凝胶与洗必泰漱口水在减少下颌第三磨牙拔除术后牙槽骨炎方面的有效性。

材料与方法

实验组或凝胶组(n = 41)在术后第一周将生物粘附性0.2%洗必泰凝胶应用于伤口,对照组或漱口水组(n = 32)在拔牙后第一周使用0.12%洗必泰漱口水。

结果

我们观察到凝胶组术后牙槽骨炎减少了70%(P = .040)。漱口水组术后牙槽骨炎的发生率为25%,而凝胶组为7.5%。

结论

得出的结论是,术后一周将生物粘附性洗必泰凝胶局部应用于手术伤口可能会降低下颌第三磨牙拔除后牙槽骨炎的发生率。

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