Casanova Manuel F, Kreczmanski Pawel, Trippe Juan, Switala Andrew, Heinsen Helmut, Steinbusch Harry W M, Schmitz Christoph
Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA.
Psychiatry Res. 2008 Apr 15;158(3):267-77. doi: 10.1016/j.psychres.2006.12.009. Epub 2008 Feb 20.
It has been postulated that the prefrontal cortices of schizophrenic patients have significant alterations in their neuropil space. However, previous results have been contradictory and inconclusive, reporting both decreases and increases in the prefrontal neuropil. The present study re-examines these findings based on measurements of cell density, and inter-cellular distances within and between cell minicolumns. The results indicate alterations in the neuropil of schizophrenic patients according to both the lamina and cortical area examined. Alterations were present in all cortical areas studied. The findings suggest an alteration in the modulatory systems innervating the cell minicolumn. Furthermore, the lack of variation in core columnarity parameters argues in favor of a defect post-dating the formation of the cell minicolumn.
据推测，精神分裂症患者的前额叶皮质在神经毡空间有显著改变。然而，先前的结果相互矛盾且尚无定论，有报告称前额叶神经毡减少和增加的情况都存在。本研究基于对细胞密度以及细胞微柱内部和之间的细胞间距离的测量，重新审视了这些发现。结果表明，根据所检查的层和皮质区域，精神分裂症患者的神经毡存在改变。在所研究的所有皮质区域均有改变。这些发现表明支配细胞微柱的调节系统发生了改变。此外，核心柱状参数缺乏变化表明存在细胞微柱形成后出现的缺陷。
