乙肝病毒感染在暴露于黄曲霉毒素B1且患肝细胞癌风险高的人群中会导致氧化应激。
Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
作者信息
Liu Zhi-Ming, Li Le-Qun, Peng Min-Hao, Liu Tang-Wei, Qin Zhong, Guo Ya, Xiao Kai-Yin, Ye Xin-Ping, Mo Xin-Shao, Qin Xue, Li Shan, Yan Lu-Nan, Shen Han-Ming, Wang LianWen, Wang Qiao, Wang Kai-bo, Liang Ren-xiang, Wei Zong-liang, Ong Choon Nam, Santella Regina M, Peng Tao
机构信息
Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Province, China.
出版信息
Cancer Lett. 2008 May 18;263(2):212-22. doi: 10.1016/j.canlet.2008.01.006. Epub 2008 Feb 15.
Abstract
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p=0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.
摘要
在中国南方的71例肝细胞癌（HCC）患者和694例对照中检测了乙肝病毒（HBV）感染、黄曲霉毒素B1（AFB1）暴露和氧化应激的生物标志物。71例HCC患者的血浆AFB1-白蛋白加合物（AAA）水平和蛋白质羰基含量（PCC）显著高于任何年龄/性别匹配的HBV血清学状态组（p<0.001）。p53-249 G-T突变阳性的HCC患者的PCC水平略高于突变阴性患者（p=0.077）。HBV感染对对照组中AFB1暴露与氧化应激生物标志物之间的关联有显著影响。我们的研究表明，在AFB1暴露人群中，HBV感染对氧化应激有显著贡献，这可能会大幅增加该地区HCC的风险。
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