Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
作者信息
Liu Zhi-Ming, Li Le-Qun, Peng Min-Hao, Liu Tang-Wei, Qin Zhong, Guo Ya, Xiao Kai-Yin, Ye Xin-Ping, Mo Xin-Shao, Qin Xue, Li Shan, Yan Lu-Nan, Shen Han-Ming, Wang LianWen, Wang Qiao, Wang Kai-bo, Liang Ren-xiang, Wei Zong-liang, Ong Choon Nam, Santella Regina M, Peng Tao
机构信息
Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi Province, China.
出版信息
Cancer Lett. 2008 May 18;263(2):212-22. doi: 10.1016/j.canlet.2008.01.006. Epub 2008 Feb 15.
Abstract
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p=0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.
摘要
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