衰老过程中犬海马CA1区和齿状回中小清蛋白免疫反应性的持续表达。

Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs.

作者信息

Hwang In Koo, Yoon Yeo Sung, Yoo Ki-Yeon, Li Hua, Sun Yuanjie, Choi Jung Hoon, Lee Choong Hyun, Huh Sung-Oh, Lee Yun Lyul, Won Moo-Ho

机构信息

Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.

出版信息

Neurosci Lett. 2008 Mar 21;434(1):99-103. doi: 10.1016/j.neulet.2008.01.035. Epub 2008 Jan 19.

DOI:10.1016/j.neulet.2008.01.035

PMID:18280652

Abstract

The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged dogs. In 1-year-old dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. In addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. In 3-year-old dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.

摘要

海马体包含多种不同类型的中间神经元。小白蛋白（PV）阳性神经元构成了表达γ-氨基丁酸（GABA）的丰富细胞亚群。作者在不同年龄犬的海马CA1区和齿状回中观察到PV免疫反应性。在1岁的犬中，在CA1区的 Oriens层和齿状回的多形层中检测到PV免疫反应性神经元。此外，在CA1区和齿状回的所有层中均观察到微弱的PV免疫反应性纤维。在3岁的犬中，CA1区和齿状回中的PV免疫反应性显著更高，并且在10岁的犬中保持这种状态。这一发现表明，PV免疫反应性中间神经元可能对年龄依赖性神经退行性过程具有高抗性。