Chen Y, Bradley S F
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor.
Exp Gerontol. 1993 Mar-Apr;28(2):145-59. doi: 10.1016/0531-5565(93)90004-w.
Decreased responsiveness of the aged to infection may be associated with a decline in monokine production. Prior studies in macrophages have used different eliciting agents, and results have varied. We assessed the effect of age on interleukin-1 (IL-1), tumor necrosis factor (TNF), and interleukin-6 (IL-6) in unelicited, thioglycollate (TG)-elicited, and complete Freund's adjuvant (CFA)-elicited peritoneal macrophages. Resident macrophages or CFA-elicited macrophages from middle aged or aged mice produced significantly less monokine bioactivity than resident or CFA-elicited macrophages from young mice. Monokine bioactivity from TG-elicited macrophages from aged and middle aged mice was significantly increased when compared with macrophages of young mice. Eliciting agents may alter macrophage populations and interactions with other cells leading to changes in monokine bioactivity with aging.
老年人对感染的反应性降低可能与单核因子产生的减少有关。先前对巨噬细胞的研究使用了不同的诱导剂，结果也各不相同。我们评估了年龄对未诱导、巯基乙酸盐（TG）诱导和完全弗氏佐剂（CFA）诱导的腹膜巨噬细胞中白细胞介素-1（IL-1）、肿瘤坏死因子（TNF）和白细胞介素-6（IL-6）的影响。中年或老年小鼠的驻留巨噬细胞或CFA诱导的巨噬细胞产生的单核因子生物活性明显低于年轻小鼠的驻留或CFA诱导的巨噬细胞。与年轻小鼠的巨噬细胞相比，老年和中年小鼠的TG诱导巨噬细胞的单核因子生物活性显著增加。诱导剂可能会改变巨噬细胞群体以及与其他细胞的相互作用，从而导致随着年龄增长单核因子生物活性发生变化。
