Nishio Shin, Ushijima Kimio, Tsuda Naotake, Takemoto Shuji, Kawano Kouichiro, Yamaguchi Tomohiko, Nishida Naoyo, Kakuma Tatsuyuki, Tsuda Hitoshi, Kasamatsu Takahiro, Sasajima Yuko, Kage Masayoshi, Kuwano Michihiko, Kamura Toshiharu
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Cancer Lett. 2008 Jun 8;264(1):36-43. doi: 10.1016/j.canlet.2008.01.020. Epub 2008 Feb 20.
Cap43 is a nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation. This study investigated associations of Cap43 expression with angiogenesis and other clinicopathological factors in cervical adenocarcinoma. The clinical records of 100 women who underwent surgery for cervical adenocarcinoma were reviewed retrospectively. Microvessel density and the expression of Cap43 and VEGF in the surgical specimens were evaluated immunohistochemically. The Cap43 expression level was significantly associated with angiogenesis, tumor diameter, stromal invasion, lymphovascular space invasion, lymph node metastasis, and histopathological differentiation. Kaplan-Meier analysis showed a significant association between the Cap43 expression level and survival: high Cap43 expression was related to poor survival. Our results suggest that increased expression of Cap43 is associated with angiogenesis and may be a poor prognostic indicator in women with cervical adenocarcinoma.
Cap43是一种镍和钙诱导型基因，在恶性肿瘤的原发性生长以及侵袭和转移中发挥重要作用，很可能是通过其诱导细胞分化的能力。本研究调查了Cap43表达与宫颈腺癌血管生成及其他临床病理因素之间的关联。回顾性分析了100例行宫颈腺癌手术的女性患者的临床记录。采用免疫组织化学方法评估手术标本中的微血管密度以及Cap43和VEGF的表达。Cap43表达水平与血管生成、肿瘤直径、间质浸润、淋巴管间隙浸润、淋巴结转移及组织病理学分化显著相关。Kaplan-Meier分析显示Cap43表达水平与生存率之间存在显著关联：Cap43高表达与生存率低相关。我们的结果表明，Cap43表达增加与血管生成有关，可能是宫颈腺癌女性患者预后不良的指标。
