Goncharuk I V, Vorobjova L I, Lukyanova N Y, Chekhun V F
National Cancer Institute, Ministry of Health of Ukraine, Kiev, Ukraine.
Exp Oncol. 2009 Sep;31(3):179-81.
This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients.
Seventy-five paraffinembedded primary tumors were stained immunohistochemically for VEGF expression, which was analysed semiquantitatively.
The significant correlation between VEGF expression and stages of disease, as well as pelvic lymph node metastasis was observed. There were determined a negative correlations between VEGF expression in tumor cells and both overall and disease-free survival.
VEGF expression in human cervical cancer may be used as a diagnostic parameter in the clinic. Our results are in accordance with literature data showing association of VEGF overexpression in tumor with a poorer patient survival.
本回顾性研究旨在确定血管内皮生长因子（VEGF）在宫颈癌细胞中的表达情况，并探讨其与患者临床病理特征及生存情况的相关性。
对75例石蜡包埋的原发性肿瘤进行免疫组织化学染色，以检测VEGF表达，并进行半定量分析。
观察到VEGF表达与疾病分期以及盆腔淋巴结转移之间存在显著相关性。肿瘤细胞中的VEGF表达与总生存期和无病生存期均呈负相关。
人宫颈癌中的VEGF表达可作为临床诊断参数。我们的结果与文献数据一致，表明肿瘤中VEGF过表达与患者较差的生存情况相关。
