Goh C L
Contact & Occupational Dermatoses Clinic, National Skin Centre, Singapore.
Contact Dermatitis. 1991 Feb;24(2):81-5. doi: 10.1111/j.1600-0536.1991.tb01656.x.
The effect of repeated exposure of cutting oil on 8 guinea pigs' skin was evaluated by visual scoring for erythema and skin water vapour loss (SVL) measurement over a 6-week period. The visual scores (measuring severity of erythema) and SVL values were significantly higher on skin treated with cutting oils (positive control) compared to untreated skin (negative control) throughout the study period. The scores and SVL values returned to near-baseline values when cutting oil application was stopped. In addition, the effect of 2 "after-work" emollient creams on 8 guinea pigs' skin repeatedly treated with a cutting oil was assessed by similar methods. The visual scores and SVL values of guinea pig skin that was repeatedly treated with the cutting oil and moisturized with "after-work" emollient creams, were significantly higher than negative and positive control guinea pig skin. It appeared that the 2 "after-work" emollient creams do not alleviate the irritant effect of the cutting oil on guinea pig skin. They appeared to aggravate the irritant effect of the cutting oil.
通过在6周内对红斑进行视觉评分和测量皮肤水分流失（SVL），评估切削油反复接触8只豚鼠皮肤的效果。在整个研究期间，与未处理的皮肤（阴性对照）相比，用切削油处理的皮肤（阳性对照）的视觉评分（测量红斑严重程度）和SVL值显著更高。当停止使用切削油时，评分和SVL值恢复到接近基线值。此外，通过类似方法评估了2种“下班后”润肤霜对8只反复用切削油处理过的豚鼠皮肤的影响。反复用切削油处理并用“下班后”润肤霜保湿的豚鼠皮肤的视觉评分和SVL值，显著高于阴性和阳性对照豚鼠皮肤。看来这2种“下班后”润肤霜并不能减轻切削油对豚鼠皮肤的刺激作用。它们似乎加剧了切削油的刺激作用。
