Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
作者信息
Demicheli C, Garnier-Suillerot A
机构信息
Laboratoire de Chimie Bioinorganique, LPCB (UA CNRS 198), UFR Biomédicale, Bobigny, France.
出版信息
Biochem Biophys Res Commun. 1991 May 31;177(1):511-7. doi: 10.1016/0006-291x(91)92013-a.
PMID:1828342
Abstract
Mithramycin (MTR) is an antitumor compound that inhibits RNA and DNA polymerase action by forming a non covalent complex with double strand DNA, in the presence of divalent cations. We have shown that in the presence of Mg2+, MTR binds to right-handed poly(dG-m5dC) as a dimer in the right-handed screwness conformation but cannot bind to left-handed poly(dG-m5dC).
摘要
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