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新西兰一家医院内科老年患者中的谵妄

Delirium among elderly general medical patients in a New Zealand hospital.

作者信息

Holden J, Jayathissa S, Young G

机构信息

AT and R Ward, Kenepuru Hospital, Hutt Hospital, Wellington, New Zealand.

出版信息

Intern Med J. 2008 Aug;38(8):629-34. doi: 10.1111/j.1445-5994.2007.01577.x. Epub 2008 Feb 14.

Abstract

BACKGROUND

Overseas studies suggest that delirium is a common and serious health problem of hospitalized elderly. There is very little information in New Zealand.

AIMS

To study prospectively the frequency and effect of delirium on a cohort of elderly general medical patients.

METHODS

Over 2 months, 317 patients were admitted to general medical wards; 70% were aged 65 years and above. These patients were screened for delirium. Comparisons were made between the delirious and non-delirious patients.

RESULTS

Fifty-six of the 216 patients screened had delirium. The prevalence and incidence of delirium were 23.4 and 5.7%, respectively. Thirty-one per cent of delirious patients had a previous history of dementia; 48% of delirious patients had multiple precipitants, most commonly infections. Delirium was associated with higher complication rates--94 versus 39% in the non-delirious patients--and a doubling in the length of hospital stay. Over 50% of delirious patients required increased supports on discharge with a general trend towards higher frequency of institutionalization. The presence of delirium was associated with increased use of neuroleptic medications, special nursing care, cot sides and restraints. A non-significant trend towards increased mortality was seen in the delirious group.

CONCLUSIONS

Delirium is a common health problem in elderly patients, associated with multiple adverse outcomes. This study highlighted the prognostic importance of diagnosing delirium. Recommendations included improved health professional education, development of guidelines including rational use of neuroleptic medication and measures to improve follow up for these patients.

摘要

背景

海外研究表明,谵妄是住院老年人常见且严重的健康问题。新西兰关于这方面的信息非常少。

目的

前瞻性研究谵妄在一组老年普通内科患者中的发生率及其影响。

方法

在两个月的时间里,317名患者入住普通内科病房;其中70%年龄在65岁及以上。对这些患者进行谵妄筛查。对发生谵妄的患者和未发生谵妄的患者进行比较。

结果

在216名接受筛查的患者中,有56人发生谵妄。谵妄的患病率和发病率分别为23.4%和5.7%。31%的谵妄患者既往有痴呆病史;48%的谵妄患者有多种诱发因素,最常见的是感染。谵妄与更高的并发症发生率相关——谵妄患者为94%,非谵妄患者为39%——且住院时间延长一倍。超过50%的谵妄患者出院时需要更多的支持,总体趋势是机构化频率更高。谵妄的存在与抗精神病药物、特殊护理、床边护栏和约束措施的使用增加有关。谵妄组有死亡率增加的趋势,但无统计学意义。

结论

谵妄是老年患者常见的健康问题,与多种不良后果相关。本研究强调了诊断谵妄的预后重要性。建议包括加强卫生专业人员教育、制定指南,包括合理使用抗精神病药物以及改善对这些患者随访的措施。

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