Szekeres-Bartho Julia
Department of Medical Microbiology, Medical School Pecs University, 12 Szigeti Str, H-7643 Pecs, Hungary.
Reprod Biomed Online. 2008 Feb;16(2):211-7. doi: 10.1016/s1472-6483(10)60576-7.
Uterine and peripheral natural killer (NK) cells represent phenotypically and functionally distinct populations. Decidual NK cells resemble the CD56(bright) peripheral NK subset in their CD56(bright) CD16(neg) phenotype but, unlike the peripheral population, they contain cytotoxic granules. The activity of NK cells is regulated by the expression of activating or inhibitory receptors on NK cells and by that of major histocompatibility complex class I molecules on target cells. The embryonic trophoblast that forms the interface between the maternal and fetal compartments expresses non-classical human leukocyte antigens that serve as ligands for NK receptors. Decidual NK cells fulfil dual tasks. During normal conditions they contribute to creating a favourable environment for placentation, but at the same time they are equipped with cytotoxic potential to fight intrauterine infections. Decidual NK activity is regulated by a complex, mutually interacting network of cytokines and hormones.
子宫自然杀伤（NK）细胞和外周NK细胞在表型和功能上是不同的群体。蜕膜NK细胞在其CD56（明亮）CD16（阴性）表型上类似于CD56（明亮）外周NK亚群，但与外周群体不同的是，它们含有细胞毒性颗粒。NK细胞的活性受NK细胞上激活或抑制性受体的表达以及靶细胞上主要组织相容性复合体I类分子的表达的调节。形成母体和胎儿隔室之间界面的胚胎滋养层表达非经典人类白细胞抗原，这些抗原作为NK受体的配体。蜕膜NK细胞执行双重任务。在正常情况下，它们有助于为胎盘形成创造有利环境，但同时它们具备对抗子宫内感染的细胞毒性潜力。蜕膜NK活性受细胞因子和激素组成的复杂、相互作用的网络调节。
