Geiger H, Bahner U, Palkovits M, Nicklas E, Hugo C, Heidland A
Department of Nephrology, University of Würzburg, FRG.
Neuroendocrinology. 1991 Jan;53(1):63-8. doi: 10.1159/000125698.
The effect of aldosterone and dexamethasone on the concentrations of atrial natriuretic peptide (ANP) in preoptic and hypothalamic nuclei was examined in adrenalectomized and intact rats. Five days after adrenalectomy, increased ANP levels in those brain areas which control water intake, i.e. in the subfornical organ, supraoptic nucleus, and in the so-called hypothalamic drinking centers (perifornical nucleus, lateral hypothalamic area) were measured. In contrast to this, adrenalectomy decreased ANP levels markedly in the organum vasculosum laminae terminalis and preoptic periventricular nucleus, which are reportedly involved in the central regulation of salt and water homeostasis. ANP contents of these two preoptic structures were restored almost completely by daily administration of 0.9% sodium chloride or aldosterone but not dexamethasone. The daily administration of aldosterone elevated ANP levels in the supraoptic, paraventricular and perifornical nuclei as well as in the lateral hypothalamus both in control and adrenalectomized rats. Dexamethasone which was without any significant effect on preoptic and hypothalamic nuclei in control rats elevated ANP levels in the supraoptic and perifornical nuclei and in the lateral hypothalamic area of adrenalectomized animals. Since neither adrenalectomy, nor aldosterone or dexamethasone treatment influenced plasma ANP levels, altered ANP contents measured in preoptic and hypothalamic nuclei may represent a direct effect of adrenal corticoids (mainly aldosterone) on brain ANP-containing neurons which may participate in the control of body fluid and electrolyte homeostasis.
在肾上腺切除的大鼠和完整大鼠中，研究了醛固酮和地塞米松对视前核和下丘脑核中心房利钠肽（ANP）浓度的影响。肾上腺切除术后5天，检测了那些控制水摄入的脑区，即穹窿下器官、视上核以及所谓的下丘脑饮水中枢（穹窿周核、下丘脑外侧区）中ANP水平的升高情况。与此相反，肾上腺切除术使终板血管器和视前室周核中的ANP水平显著降低，据报道这两个脑区参与盐和水平衡的中枢调节。通过每日给予0.9%氯化钠或醛固酮，这两个视前结构中的ANP含量几乎完全恢复，但地塞米松则无此作用。在对照大鼠和肾上腺切除大鼠中，每日给予醛固酮均可使视上核、室旁核、穹窿周核以及下丘脑外侧区的ANP水平升高。在对照大鼠中对视前核和下丘脑核无显著影响的地塞米松，可使肾上腺切除动物的视上核、穹窿周核以及下丘脑外侧区的ANP水平升高。由于肾上腺切除术、醛固酮或地塞米松治疗均未影响血浆ANP水平，因此在视前核和下丘脑核中测得的ANP含量改变可能代表肾上腺皮质激素（主要是醛固酮）对脑内含ANP神经元的直接作用，这些神经元可能参与体液和电解质平衡的控制。
