Palkovits M, Bahner U, Geiger H, Fodor M, Heidland A
Laboratory of Neuromorphology, Semmelweis University Medical School, Budapest, Hungary.
Neuroendocrinology. 1992 Aug;56(2):204-7. doi: 10.1159/000126229.
Twelve days after hypophysectomy depleted atrial natriuretic polypeptide (ANP) concentrations were measured in the plasma and in 8 of 18 microdissected brain nuclei of rats. Reduced ANP levels were found in brain structures (subfornical organ, organum vasculosum laminae terminalis, preoptic and hypothalamic periventricular nuclei, paraventricular nucleus, lateral hypothalamic area), which are directly involved in the central regulations of salt and fluid homeostasis, as well as in the medial amygdaloid nucleus and the locus ceruleus. ANP concentrations in the median eminence, medial preoptic and arcuate nuclei did not alter by hypophysectomy. Elevated ANP concentrations were measured only in the supraoptic nucleus of hypophysectomized rats.
垂体切除术后12天，测定了大鼠血浆以及18个经显微解剖的脑核团中8个核团的心房利钠多肽（ANP）浓度。在直接参与盐和液体稳态中枢调节的脑结构（穹窿下器官、终板血管器、视前区和下丘脑室周核、室旁核、下丘脑外侧区）以及杏仁内侧核和蓝斑中发现ANP水平降低。垂体切除术后，正中隆起、内侧视前核和弓状核中的ANP浓度没有改变。仅在垂体切除的大鼠视上核中测得ANP浓度升高。
