Palkovits M, Geiger H, Bahner U, Fodor M, Pammer C
First Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Miner Electrolyte Metab. 1990;16(1):42-7.
Concentrations of atrial natriuretic factor (ANF) were measured in discrete brain nuclei by radioimmunoassay in rats. Alterations in the salt and fluid homeostasis and aldosterone treatment resulted in marked changes of ANF levels in the preoptic-hypothalamic periventricular structures including the organum vasculosum laminae terminalis, in the subfornical organ and the perifornical nucleus. Furthermore, marked changes were observed in ANF levels of these nuclei in various types of renal hypertensions. Altered ANF levels were found in several brain nuclei (locus coeruleus, dorsal raphe nucleus, tegmentum pontis, nucleus of the solitary tract) of animals with diabetes insipidus or spontaneous hypertension.
通过放射免疫分析法测定了大鼠离散脑核中的心房利钠因子（ANF）浓度。盐和液体稳态的改变以及醛固酮治疗导致视前 - 下丘脑室周结构（包括终板血管器）、穹窿下器和穹窿周核中ANF水平发生显著变化。此外，在各种类型的肾性高血压中，这些核团的ANF水平也观察到显著变化。在患有尿崩症或自发性高血压的动物的几个脑核（蓝斑、中缝背核、脑桥被盖、孤束核）中发现ANF水平发生改变。
