DNA双链断裂修复的当前研究热点。

Current topics in DNA double-strand break repair.

作者信息

Kobayashi Junya, Iwabuchi Kuniyoshi, Miyagawa Kiyoshi, Sonoda Eiichiro, Suzuki Keiji, Takata Minoru, Tauchi Hiroshi

机构信息

Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan.

出版信息

J Radiat Res. 2008 Mar;49(2):93-103. doi: 10.1269/jrr.07130. Epub 2008 Feb 19.

DOI:10.1269/jrr.07130

PMID:18285658

Abstract

DNA double strand break (DSB) is one of the most critical types of damage which is induced by ionizing radiation. In this review, we summarize current progress in investigations on the function of DSB repair-related proteins. We focused on recent findings in the analysis of the function of proteins such as 53BP1, histone H2AX, Mus81-Eme1, Fanc complex, and UBC13, which are found to be related to homologous recombination repair or to non-homologous end joining. In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed.

摘要

DNA双链断裂（DSB）是电离辐射诱导产生的最关键的损伤类型之一。在本综述中，我们总结了DSB修复相关蛋白功能研究的当前进展。我们重点关注了53BP1、组蛋白H2AX、Mus81-Eme1、范可尼贫血复合体（Fanc complex）和UBC13等蛋白功能分析的最新发现，这些蛋白被发现与同源重组修复或非同源末端连接有关。除了这些蛋白在DSB修复中的功能外，还讨论了DSB诱导后核灶形成的生物学功能。