Järvisalo M J, Hutri-Kähönen N, Juonala M, Mikkilä V, Räsänen L, Lehtimäki T, Viikari J, Raitakari O T
Department of Clinical Physiology, University of Turku, Turku, Finland.
Eur J Clin Nutr. 2009 May;63(5):640-5. doi: 10.1038/ejcn.2008.17. Epub 2008 Feb 20.
BACKGROUND/OBJECTIVES: Breast feeding in infancy may be associated with reduced cardiovascular morbidity in adulthood. We examined the association between breast feeding in infancy and arterial function and structure in adulthood in a population-based cohort of Finnish adults.
SUBJECTS/METHODS: Noninvasive ultrasound was used to measure brachial artery flow-mediated dilatation (FMD), carotid artery intima-media thickness (IMT) and carotid artery compliance (CAC) in 1667 young adults participating in the Cardiovascular Risk in Young Finns Study with data on early nutrition.
Maximal FMD was higher in breast-fed men compared to formula-fed men (7.2+/-4.0 vs 5.9+/-3.4%, P=0.029) while no differences were seen between breast-fed and formula-fed women (8.9+/-4.5 vs 8.8+/-5.0%, P=0.84). In men, the multivariable correlates of FMD included the group variable for breast feeding (P=0.014), birth weight (P=0.043), waist circumference (P<0.001) and baseline brachial artery diameter (P<0.001). In women, the multivariable correlates of FMD were birth weight (P=0.02), waist circumference (P<0.001) and brachial artery baseline diameter (P<0.001). Breast feeding was not significantly associated with IMT or CAC in multivariable models.
Adult men who have been breast fed have better brachial endothelial function compared to men who have been formula fed.
背景/目的：婴儿期母乳喂养可能与成年后心血管疾病发病率降低有关。我们在一个基于人群的芬兰成年人队列中，研究了婴儿期母乳喂养与成年后动脉功能和结构之间的关联。
受试者/方法：对1667名参与芬兰年轻人心血管风险研究且有早期营养数据的年轻人，使用无创超声测量肱动脉血流介导的扩张（FMD）、颈动脉内膜中层厚度（IMT）和颈动脉顺应性（CAC）。
母乳喂养的男性最大FMD高于配方奶喂养的男性（7.2±4.0对5.9±3.4%，P=0.029），而母乳喂养和配方奶喂养的女性之间未观察到差异（8.9±4.5对8.8±5.0%，P=0.84）。在男性中，FMD的多变量相关因素包括母乳喂养组变量（P=0.014）、出生体重（P=0.043）、腰围（P<0.001）和肱动脉基线直径（P<0.001）。在女性中，FMD的多变量相关因素是出生体重（P=0.02）、腰围（P<0.001）和肱动脉基线直径（P<0.001）。在多变量模型中，母乳喂养与IMT或CAC无显著关联。
与配方奶喂养的男性相比，母乳喂养的成年男性肱动脉内皮功能更好。
