Mangia A, Burra P, Ciancio A, Fagiuoli S, Guido M, Picciotto A, Fabrizi F
Division of Gastroenterology, General Hospital, IRCCS, San Giovanni Rotondo - Italy.
Int J Artif Organs. 2008 Jan;31(1):15-33. doi: 10.1177/039139880803100104.
The management of hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) is complex and represents a particular concern since numerous issues, such as antiviral therapy in dialysis patients and post renal transplant, and prevention of HCV spread within dialysis units, remain unresolved. An enormous body of literature has been published on HCV in the CKD population; however, clinical evidence on important issues is mostly based on uncontrolled clinical trials or retrospective surveys. The aim of this paper is to provide a systematic review of the literature. Responses to the critical issues have been developed by a consensus of experts, endorsed by the Italian Association for the Study of the Liver (AISF) and some clinical recommendations have been added.
丙型肝炎病毒（HCV）感染的慢性肾脏病（CKD）患者的管理十分复杂，是一个特别值得关注的问题，因为诸多问题仍未得到解决，比如透析患者和肾移植后的抗病毒治疗，以及预防HCV在透析单位内传播。关于CKD人群中HCV的文献数量众多；然而，重要问题的临床证据大多基于非对照临床试验或回顾性调查。本文旨在对相关文献进行系统综述。针对关键问题的应对措施是由专家达成共识制定的，得到了意大利肝脏研究协会（AISF）的认可，并增加了一些临床建议。
