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DOG1阳性原发性肠系膜平滑肌肉瘤:1例报告并文献复习

DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature.

作者信息

Koufopoulos Nektarios, Damaskou Vasileia, Siozopoulou Vasiliki, Kokoropoulos Panagiotis, Gouloumis Alina-Roxani, Arkadopoulos Nikolaos, Panayiotides Ioannis G

机构信息

Pathology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.

Pathology, Antwerp University Hospital, Edegem, BEL.

出版信息

Cureus. 2022 May 23;14(5):e25263. doi: 10.7759/cureus.25263. eCollection 2022 May.

DOI:10.7759/cureus.25263
PMID:35755504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9224980/
Abstract

The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient operated on for a primary mesenteric leiomyosarcoma with a positive immunostain for DOG1, despite having no or mutations on molecular analysis. Moreover, we review the pertinent literature.

摘要

肠系膜是恶性胃肠道肿瘤转移扩散的常见部位。另一方面,原发性肠系膜肿瘤非常罕见;淋巴瘤最为常见,其次是良性和恶性间叶组织肿瘤。我们报告一例43岁患者,因原发性肠系膜平滑肌肉瘤接受手术,尽管分子分析未发现 或 突变,但DOG1免疫染色呈阳性。此外,我们还回顾了相关文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9183/9224980/da32cf9d6a28/cureus-0014-00000025263-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9183/9224980/b19d0bf7283c/cureus-0014-00000025263-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9183/9224980/da32cf9d6a28/cureus-0014-00000025263-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9183/9224980/b19d0bf7283c/cureus-0014-00000025263-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9183/9224980/da32cf9d6a28/cureus-0014-00000025263-i02.jpg

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本文引用的文献

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Indian J Cancer. 2021 Apr-Jun;58(2):267-272. doi: 10.4103/ijc.IJC_705_19.
2
Update on Molecular Genetics of Gastrointestinal Stromal Tumors.胃肠道间质瘤分子遗传学的最新进展
Diagnostics (Basel). 2021 Jan 28;11(2):194. doi: 10.3390/diagnostics11020194.
3
Primary Leiomyosarcoma of the Mesentery: A Case Report With Review of Literature.肠系膜原发性平滑肌肉瘤:一例报告并文献复习
Cureus. 2020 Oct 3;12(10):e10777. doi: 10.7759/cureus.10777.
4
An unusual case of dedifferentiated leiomyosarcoma of the primary mesentery mimicking ovarian cancer.一例罕见的原发性肠系膜去分化平滑肌肉瘤,酷似卵巢癌。
Int J Clin Exp Pathol. 2019 Nov 1;12(11):4150-4155. eCollection 2019.
5
Posterior reversible encephalopathy syndrome (PRES) in mesenteric leiomyosarcoma: A case report.肠系膜平滑肌肉瘤中的后部可逆性脑病综合征(PRES):一例报告。
Int J Surg Case Rep. 2018;49:96-101. doi: 10.1016/j.ijscr.2018.04.043. Epub 2018 May 29.
6
Primary Leiomyosarcoma of the Mesentery: A Case Report.肠系膜原发性平滑肌肉瘤:一例报告
Iran J Med Sci. 2017 Sep;42(5):505-508.
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Rare case of primary leiomyosarcoma of sigmoid mesocolon.乙状结肠系膜原发性平滑肌肉瘤罕见病例。
BMJ Case Rep. 2017 Sep 15;2017:bcr-2017-219826. doi: 10.1136/bcr-2017-219826.
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