Bogaerts Sofie, Vander Poorten Vincent, Nuyts Sandra, Van den Bogaert Walter, Jorissen Mark
ENT Department HNS, UZ Leuven, Leuven, Belgium.
Head Neck. 2008 Jun;30(6):728-36. doi: 10.1002/hed.20771.
Adenocarcinoma is the most frequent histological subtype of paranasal sinus malignancy diagnosed in Belgium. Classical treatment consists of an external surgical approach (lateral rhinotomy with medial maxillectomy or craniofacial resection) followed by radiotherapy. The role, possibilities, and limitations of endoscopic sinus surgery (ESS) are to date unknown.
We studied 44 patients with primary (not treated previously) adenocarcinoma treated with endoscopic sinus surgery and radiotherapy between 1992 and 2004.
The median follow-up of the patients alive at the end of the study period was 36 months. For the 3-year follow-up, the overall survival, disease-specific survival, and local control rate were 81%, 91%, and 73%, respectively. Corresponding rates for the 5-year follow-up were 53%, 83%, and 62%. Union Internationale Contre le Cancer T classification did not appear to influence these results.
Endoscopic sinus surgery followed by radiotherapy for primary adenocarcinoma of the paranasal sinuses gives oncological results comparable to those of standard external approaches.
在比利时，腺癌是鼻腔鼻窦恶性肿瘤中最常见的组织学亚型。传统治疗方法包括外科手术（外侧鼻切开术联合上颌骨内侧切除术或颅面切除术），术后进行放疗。迄今为止，内镜鼻窦手术（ESS）的作用、可能性及局限性尚不清楚。
我们研究了1992年至2004年间接受内镜鼻窦手术和放疗的44例原发性（既往未治疗过）腺癌患者。
研究期末存活患者的中位随访时间为36个月。3年随访时，总生存率、疾病特异性生存率和局部控制率分别为81%、91%和73%。5年随访时的相应比率分别为53%、83%和62%。国际抗癌联盟（Union Internationale Contre le Cancer）T分期似乎并未影响这些结果。
对于原发性鼻窦腺癌，内镜鼻窦手术联合放疗的肿瘤学疗效与标准外科手术相当。
