Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy.
Curr Oncol Rep. 2011 Apr;13(2):138-44. doi: 10.1007/s11912-011-0151-6.
Malignant tumors of the sinonasal tract are rare, accounting for only 1% of all malignancies. Although they are associated with substantial histological heterogeneity, surgery plays a key role in their management. This review addresses the evolution of current treatments in view of the introduction of endoscopic resection techniques. The absence of facial incisions and osteotomies, decreased hospitalization time, better control of bleeding, improved visualization of tumor borders, and reduced morbidity and mortality rate are the major advantages of endoscopic techniques in comparison to traditional external approaches. The major criticisms focus on oncologic results in view of the short/intermediate follow-up of large series, which have commonly grouped together several histologies that may be associated with different prognoses. Since prospective studies contrasting the results of endoscopic and craniofacial resections are difficult to carry out given the rarity of the disease together with ethical issues, the creation of a large database would favor the analysis of several variables related to the patient, tumor, and treatment on survival performed on a large number of patients.
鼻腔鼻窦恶性肿瘤较为罕见，仅占所有恶性肿瘤的 1%。尽管它们具有明显的组织学异质性，但手术在其治疗中起着关键作用。鉴于内镜切除术技术的引入，本综述讨论了当前治疗方法的演变。与传统的外部方法相比，内镜技术具有以下优点：无需面部切口和骨切开术、住院时间缩短、更好地控制出血、改善肿瘤边界的可视化以及降低发病率和死亡率。主要的批评意见集中在肿瘤学结果上，因为大多数大型系列研究的随访时间较短/中期，这些研究通常将几种可能与不同预后相关的组织学分组在一起。由于该疾病的罕见性以及伦理问题，很难开展内镜与颅面切除术结果对比的前瞻性研究，因此创建一个大型数据库将有利于对大量患者的生存进行与患者、肿瘤和治疗相关的多个变量的分析。
