Gunathilake H M D R, Sirimanna G M P, Schürer N Y
National Hospital of Sri Lanka, Colombo.
Ceylon Med J. 2007 Dec;52(4):125-9. doi: 10.4038/cmj.v52i4.913.
Initially linked to antimicrobial function, the acidic skin pH plays a key role in permeability barrier homeostasis and integrity of the stratum corneum. Barrier recovery is delayed when acutely perturbed skin sites are exposed to a neutral pH.
To evaluate the pH of commercially available rinse-off products in Sri Lanka, and the effect of detergent rinses on skin pH and its recovery rate.
The pH of 18 rinse-off products was determined using pH indicator paper and a pH meter. The effect of an alkaline (pH 9) and an acid (pH 5.5) rinse-off product on the hand skin pH was compared in 48 healthy volunteers after single and multiple applications. The skin pH of the dorsum of hands was measured in nurses before (n = 131) and during (n = 40) a duty shift that involved frequent hand washing using alkaline soap.
Soaps available in Sri Lanka have a pH of 9.1-10.5. The pH of syndets and cleansers range from 5.5-7.0. Five minutes after hand washing, the mean skin pH increased by 1.7 +/- SD 0.5 pH units with alkaline soap, and by 0.8 +/- SD 0.4 pH units with acidic cleanser (p < 0.0001). Recovery of pH was slower when alkaline soap was used. The increase in skin pH was significantly greater when hands were repetitively washed with alkaline soap (p < 0.0001). The mean skin pH values of nurses before (4.9 +/- SD 0.4) and during (5.7 +/- SD 0.7) the work shift were significantly different (p < 0.0001).
Alkalinisation with rinse-off products increases the skin pH with potential functional and clinical implications.
皮肤酸性pH值最初与抗菌功能相关,在角质层的渗透屏障稳态和完整性中起关键作用。当急性受损的皮肤部位暴露于中性pH值环境时,屏障恢复会延迟。
评估斯里兰卡市售冲洗产品的pH值,以及洗涤剂冲洗对皮肤pH值及其恢复率的影响。
使用pH试纸和pH计测定18种冲洗产品的pH值。在48名健康志愿者单次和多次使用后,比较了碱性(pH 9)和酸性(pH 5.5)冲洗产品对手部皮肤pH值的影响。在护士值勤前(n = 131)和值勤期间(n = 40)测量其手背皮肤pH值,值勤期间涉及频繁使用碱性肥皂洗手。
斯里兰卡市售肥皂的pH值为9.1 - 10.5。合成洗涤剂和洁面产品的pH值范围为5.5 - 7.0。洗手五分钟后,使用碱性肥皂时皮肤平均pH值增加1.7±标准差0.5个pH单位,使用酸性洁面产品时增加0.8±标准差0.4个pH单位(p < 0.0001)。使用碱性肥皂时pH值恢复较慢。用碱性肥皂反复洗手时,皮肤pH值的升高明显更大(p < 0.0001)。护士值勤前(4.9±标准差0.4)和值勤期间(5.7±标准差0.7)的皮肤平均pH值有显著差异(p < 0.0001)。
冲洗产品导致的碱化会增加皮肤pH值,具有潜在的功能和临床意义。