Madhavan Jagadeesan, Ganesh Anuradha, Roy Joseph, Biswas Jyotirmay, Kumaramanickavel Govindasamy
SNONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.
J Pediatr Ophthalmol Strabismus. 2008 Jan-Feb;45(1):22-5. doi: 10.3928/01913913-20080101-16.
To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma.
Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed.
Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors.
Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.
确定视网膜母细胞瘤中肿瘤细胞分化与诊断时年龄之间的关系。
回顾性分析170例行眼球摘除术治疗的视网膜母细胞瘤患者的病历。分析诊断时的年龄和组织病理学特征。
高分化肿瘤比低分化肿瘤出现得早。高分化肿瘤在1岁时出现频率最高，低分化肿瘤在3岁时出现频率最高（P <.0001）。双侧高分化肿瘤比双侧低分化肿瘤出现得早。同样，单侧高分化肿瘤比单侧低分化肿瘤出现得早。
在视网膜母细胞瘤中，无论肿瘤位于单侧还是双侧，分化良好的肿瘤比分化不良的肿瘤出现得早。
