视网膜母细胞瘤新玫瑰花结的分子病理学解释

Das Dipankar, Deka Panna, Bhattacharjee Kasturi, Barman Manab Jyoti, Bhattacharjee Harsha, Misra Divakant, Saxena Rushil Kumar, Bhattacharyya Anusuya, Deka Apurba

Department of Ocular Pathology, Uvea and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Indian J Ophthalmol. 2017 Aug;65(8):764-767. doi: 10.4103/ijo.IJO_316_16.

Newly described retinoblastoma (RB) rosettes have various kinds of pathological significance. Some of their characteristics have been revealed in this immunohistochemistry study. Five paraffin-embedded eyeballs with RB and new rosettes were studied for neuron-specific enolase (NSE), p53, p16, BAX, c-Myc, glial fibrillary acidic protein, synaptophysin, and chromogranin. They were compared and interpreted using control specimens. NSE, P53, and P16 were significantly expressed in the cells of the new rosettes. The presence of new RB rosettes that mostly have histopathological high-risk factors and p53 positivity may be a strong marker of poor prognosis of RB.

新描述的视网膜母细胞瘤（RB）菊形团具有多种病理意义。本免疫组织化学研究揭示了它们的一些特征。对5个含有RB和新菊形团的石蜡包埋眼球进行了神经元特异性烯醇化酶（NSE）、p53、p16、BAX、c-Myc、胶质纤维酸性蛋白、突触素和嗜铬粒蛋白的研究。使用对照标本对它们进行比较和解读。NSE、P53和P16在新菊形团的细胞中显著表达。大多数具有组织病理学高危因素和p53阳性的新RB菊形团的存在可能是RB预后不良的有力标志物。