钙拮抗剂PN 200 - 110可抑制可卡因的强化特性。
The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine.
作者信息
Pani L, Kuzmin A, Martellotta M C, Gessa G L, Fratta W
机构信息
B. B. Brodie, Department of Neuroscience, University of Cagliari, Italy.
出版信息
Brain Res Bull. 1991 Mar;26(3):445-7. doi: 10.1016/0361-9230(91)90022-c.
The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm. PN 200-110 in nonsedative doses (0.62-1.25-2.5 mg/kg SC) was able to inhibit cocaine-(10 mg/kg IP) induced place preference with ED50 1.57 (0.88-2.58). The results suggest a possible use of DHPs in the treatment of cocaine-related disorders.
使用条件性位置偏爱范式研究了二氢吡啶（DHP）类钙拮抗剂PN 200-110对可卡因强化特性的影响。非镇静剂量（0.62 - 1.25 - 2.5mg/kg皮下注射）的PN 200-110能够抑制可卡因（10mg/kg腹腔注射）诱导的位置偏爱，半数有效剂量（ED50）为1.57（0.88 - 2.58）。结果提示二氢吡啶类药物可能用于治疗与可卡因相关的疾病。
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