血管生成中的整合素亲和力调节
Integrin affinity modulation in angiogenesis.
作者信息
Mahabeleshwar Ganapati H, Chen Juhua, Feng Weiyi, Somanath Payaningal R, Razorenova Olga V, Byzova Tatiana V
机构信息
Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
出版信息
Cell Cycle. 2008 Feb 1;7(3):335-47. doi: 10.4161/cc.7.3.5234. Epub 2007 Nov 1.
Integrins, transmembrane glycoprotein receptors, play vital roles in pathological angiogenesis, but their precise regulatory functions are not completely understood and remain controversial. This study aims to assess the regulatory functions of individual beta subunits of endothelial integrins in angiogenic responses induced by vascular endothelial growth factor (VEGF). Inhibition of expression of beta(1), beta(3), or beta(5) integrins in endothelial cells resulted in down regulation of EC adhesion and migration on the primary ligand for the corresponding integrin receptor, while no effects on the recognition of other ligands were detected. Although inhibition of expression of each subunit substantially affected capillary growth stimulated by VEGF, the loss of beta(3) integrin was the most inhibitory.
整合素作为跨膜糖蛋白受体，在病理性血管生成中发挥着至关重要的作用，但其确切的调节功能尚未完全明确，仍存在争议。本研究旨在评估内皮整合素各个β亚基在血管内皮生长因子（VEGF）诱导的血管生成反应中的调节功能。在内皮细胞中抑制β1、β3或β5整合素的表达，会导致内皮细胞（EC）在相应整合素受体的主要配体上的黏附和迁移下调，而未检测到对其他配体识别的影响。尽管抑制每个亚基的表达都显著影响了VEGF刺激的毛细血管生长，但β3整合素的缺失抑制作用最强。
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