Prevention and Research Center, Weinberg Center for Women's Health and Medicine, Mercy Medical Center, 227 Street Paul Place, 6th Floor, Baltimore, MD 21202, USA.
PPAR Res. 2008;2008:276581. doi: 10.1155/2008/276581.
The primary aim of this study was to examine prospectively the associations between 5 peroxisome proliferator-activated receptor (PPAR) single nucleotide polymorphisms (SNPs) and cardiovascular morbidity and mortality in a community-based cohort study in Washington County, Maryland. Data were analyzed from 9,364 Caucasian men and women participating in CLUE-II. Genotyping on 5 PPAR polymorphisms was conducted using peripheral DNA samples collected in 1989. The followup period was from 1989 to 2003. The results showed that there were no statistically significant associations between the PPAR SNPs and cardiovascular deaths or events. In contrast, statistically significant age-adjusted associations were observed for PPARG rs4684847 with both baseline body mass and blood pressure, and for PPARG rs709158, PPARG rs1175543, and PPARD rs2016520 with baseline cholesterol levels. Future studies should be conducted to confirm these findings and to explore the associations in populations with greater racial and ethnic diversity.
本研究的主要目的是前瞻性地研究马里兰州华盛顿县社区队列研究中 5 个过氧化物酶体增殖物激活受体（PPAR）单核苷酸多态性（SNP）与心血管发病率和死亡率之间的关系。对参与 CLUE-II 的 9364 名白种男女进行数据分析。1989 年采集外周血 DNA 样本进行 5 个 PPAR 多态性的基因分型。随访期从 1989 年至 2003 年。结果显示，PPAR SNPs 与心血管死亡或事件之间无统计学显著相关性。相反，PPARG rs4684847 与基线体重和血压，以及 PPARG rs709158、PPARG rs1175543 和 PPARD rs2016520 与基线胆固醇水平之间存在统计学显著的年龄调整相关性。未来的研究应进行以确认这些发现，并探索在种族和民族多样性更大的人群中的相关性。
