足月儿及其母亲分娩时头发中的汞含量与钙泵活性呈负相关。
Hair mercury negatively correlates with calcium pump activity in human term newborns and their mothers at delivery.
作者信息
Huel Guy, Sahuquillo Josiane, Debotte Ginette, Oury Jean-François, Takser Larissa
机构信息
Institut National de la Santé et de la Recherche Médicale (INSERM-IFR69-U780), Recherche en Epidemiologie et en Biostatistique, Villejuif, France.
出版信息
Environ Health Perspect. 2008 Feb;116(2):263-7. doi: 10.1289/ehp.10381.
BACKGROUND
Calcium homeostasis is a known target of several environmental toxicants including lead and mercury.
OBJECTIVE
Our goal was to determine the relationship between Hg exposure and erythrocyte Ca pump activity in women at delivery and in their newborns.
METHODS
We determined total Hg as well as Pb concentrations in 81 hair and blood samples obtained at delivery. Basal and calmodulin-stimulated Ca pump activity was measured in red blood cells from cord blood and maternal erythrocyte plasma membranes.
RESULTS
Maternal hair Hg negatively correlates with Ca pump activity in maternal and cord blood erythrocytes. Pb and Hg both independently correlate negatively with Ca pump activity without any statistically significant interaction. After adjustment for potential confounders, Pb and Hg explain about 30% and 7% of total variance of Ca pump activity in newborns and mothers, respectively.
CONCLUSION
Our findings confirm results reported in previous experimental studies and support the use of biomarkers in newborns from general population.
背景
钙稳态是包括铅和汞在内的几种环境毒物的已知作用靶点。
目的
我们的目标是确定分娩时女性及其新生儿汞暴露与红细胞钙泵活性之间的关系。
方法
我们测定了分娩时采集的81份头发和血液样本中的总汞以及铅浓度。测量了脐带血和母体红细胞质膜中红细胞的基础钙泵活性和钙调蛋白刺激的钙泵活性。
结果
母体头发汞含量与母体和脐带血红细胞中的钙泵活性呈负相关。铅和汞均与钙泵活性独立呈负相关，且无任何统计学上的显著相互作用。在对潜在混杂因素进行校正后，铅和汞分别解释了新生儿和母亲钙泵活性总变异的约30%和7%。
结论
我们的研究结果证实了先前实验研究报告的结果，并支持在普通人群的新生儿中使用生物标志物。
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