来自南非海洋软体动物三角帆蚌的生物活性代谢产物。

Bioactive metabolites from the South African marine mollusk Trimusculus costatus.

作者信息

van Wyk Albert W W, Gray Christopher A, Whibley Catherine E, Osoniyi Omolaja, Hendricks Denver T, Caira Mino R, Davies-Coleman Michael T

机构信息

Department of Chemistry, Rhodes University, Grahamstown, South Africa.

出版信息

J Nat Prod. 2008 Mar;71(3):420-5. doi: 10.1021/np070612y. Epub 2008 Feb 21.

DOI:10.1021/np070612y

PMID:18288809

Abstract

A reinvestigation of extracts of the endemic South African intertidal limpet Trimusculus costatus yielded the known labdane diterpenes 6beta,7alpha-diacetoxylabda-8,13 E-dien-15-ol ( 1) and 2alpha,6beta,7alpha-triacetoxylabda-8,13 E-dien-15-ol ( 2) and three new metabolites, 6beta,7alpha,15-triacetoxylabda-8,13 E-diene ( 3), 3alpha,11-dihydroxy-9,11-seco-cholest-4,7-dien-6,9-dione ( 4), and cholest-7-en-3,5,7-triol ( 5). Chiral derivatization and X-ray analysis were used to confirm the labdane absolute configuration of 2. Compounds 1, 2 and 4 exhibited moderate activity (3-25 microM) against the WHCO1 human esophageal cancer cell line.

摘要

对南非本土潮间带帽贝Trimusculus costatus提取物的重新研究得到了已知的半日花烷二萜6β,7α - 二乙酰氧基半日花 - 8,13 E - 二烯 - 15 - 醇（1）和2α,6β,7α - 三乙酰氧基半日花 - 8,13 E - 二烯 - 15 - 醇（2）以及三种新的代谢产物，6β,7α,15 - 三乙酰氧基半日花 - 8,13 E - 二烯（3）、3α,11 - 二羟基 - 9,11 - 开环胆甾 - 4,7 - 二烯 - 6,9 - 二酮（4）和胆甾 - 7 - 烯 - 3,5,7 - 三醇（5）。采用手性衍生化和X射线分析确定了2的半日花烷绝对构型。化合物1、2和4对WHCO1人食管癌细胞系表现出中等活性（3 - 25 microM）。