van Driel Ian R, Ang Desmond K Y
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
J Gastroenterol Hepatol. 2008 Feb;23(2):171-7. doi: 10.1111/j.1440-1746.2007.05278.x.
Regulatory T cells curb unwanted immune responses and regulate responses to microflora and it is now clear that regulatory T cells play an important role in a number of chronic inflammatory diseases of the gut. First, regulatory T cells are crucial in controlling immune responses to gastric autoantigens and thus preventing autoimmune gastritis and pernicious anemia. Second, regulatory T cells may modulate the response to Helicobacter pylori, thus affecting the ability of the immune system to clear the pathogen and mediate damage to the gastric mucosa. Finally, regulatory T cells play an important role in preventing damaging inflammatory responses to commensal organisms in the lower gut, thus guarding against inflammatory bowel diseases. In the present review, we examine the actions of regulatory T cells in the gut and conclude that further understanding of regulatory T cell biology may lead to new therapeutic approaches to chronic gastrointestinal disease.
调节性T细胞可抑制不必要的免疫反应，并调节对微生物群的反应，现在很清楚，调节性T细胞在多种肠道慢性炎症性疾病中发挥着重要作用。首先，调节性T细胞在控制对胃自身抗原的免疫反应从而预防自身免疫性胃炎和恶性贫血方面至关重要。其次，调节性T细胞可能调节对幽门螺杆菌的反应，从而影响免疫系统清除病原体和介导胃黏膜损伤的能力。最后，调节性T细胞在预防下消化道共生生物引发的破坏性炎症反应方面发挥重要作用，从而预防炎症性肠病。在本综述中，我们研究了调节性T细胞在肠道中的作用，并得出结论，进一步了解调节性T细胞生物学可能会带来治疗慢性胃肠疾病的新方法。
