Laboratory of Hepatic Viral Diseases, Singapore Institute for Clinical Sciences, Agency of Science Technology and Research (A*Star), 30 Medical Drive, 117609, Singapore.
Singapore Immunology Network, Agency of Science Technology and Research (A*Star), Singapore.
Viruses. 2009 Sep;1(2):91-103. doi: 10.3390/v1020091. Epub 2009 Jul 27.
The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in patients with resolved or chronic HBV infection and analyze how the liver environment can directly modulate HBV-immunity.
成功控制 HBV 感染需要有效扩展适应性免疫系统的不同元素（B 细胞、辅助性和细胞毒性 T 细胞），由于 HBV 的嗜肝性质，这些元素需要在肝实质中发挥作用。在这方面，我们将讨论在已解决或慢性 HBV 感染患者中 HBV 免疫的广泛特征，并分析肝环境如何直接调节 HBV 免疫。
