Kim J A, Park H S
Department of Family Medicine, Cheil General Hospital & Women's Health Care Center, Kwandong University, College of Medicine, Seoul, South Korea.
Diabetes Metab. 2008 Apr;34(2):126-30. doi: 10.1016/j.diabet.2007.10.012. Epub 2008 Mar 4.
The association between abdominal fat distribution and cardiometabolic risk factors using direct measures of abdominal fat in adolescents has not been extensively researched. This study was designed to investigate the association between visceral and subcutaneous fat and cardiometabolic risk factors, in obese Korean adolescents. The study enrolled 175 adolescents (72 boys, 103 girls), from ages nine to 19 years, who were referred to the Obesity Clinic of Asan Medical Center. Body mass index (BMI) and waist circumference (WC) were measured for each study participant. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were calculated by computed tomography. Blood pressure, fasting plasma glucose, total cholesterol, triglycerides, HDL cholesterol, insulin and homeostasis model assessment (HOMA) score were measured. Systolic blood pressure, HDL cholesterol, fasting insulin and the HOMA score were significantly correlated with BMI, WC, VAT and SAT. In addition, VAT was significantly correlated with diastolic blood pressure and triglyceride levels. On multiple regression analysis, VAT was independently correlated with blood pressure, triglycerides, HDL cholesterol, fasting insulin and the HOMA score, while SAT was independently correlated with systolic blood pressure, fasting insulin and the HOMA score. This study determined that cardiovascular risk factors are closely associated with VAT, while insulin resistance is closely associated with both VAT and SAT among obese Korean adolescents.
在青少年中，利用腹部脂肪的直接测量方法来研究腹部脂肪分布与心脏代谢危险因素之间的关联尚未得到广泛研究。本研究旨在调查肥胖韩国青少年内脏脂肪和皮下脂肪与心脏代谢危险因素之间的关联。该研究招募了175名9至19岁的青少年（72名男孩，103名女孩），他们均被转诊至峨山医疗中心肥胖诊所。对每位研究参与者测量体重指数（BMI）和腰围（WC）。通过计算机断层扫描计算内脏脂肪组织（VAT）和皮下脂肪组织（SAT）面积。测量血压、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、胰岛素和稳态模型评估（HOMA）评分。收缩压、高密度脂蛋白胆固醇、空腹胰岛素和HOMA评分与BMI、WC、VAT和SAT显著相关。此外，VAT与舒张压和甘油三酯水平显著相关。多元回归分析显示，VAT与血压、甘油三酯、高密度脂蛋白胆固醇、空腹胰岛素和HOMA评分独立相关，而SAT与收缩压、空腹胰岛素和HOMA评分独立相关。本研究确定，在肥胖韩国青少年中，心血管危险因素与VAT密切相关，而胰岛素抵抗与VAT和SAT均密切相关。
