正常体重及超重儿童、青少年和成年人个体脂肪储存与心血管代谢特征之间的关联。
Association between individual fat depots and cardio-metabolic traits in normal- and overweight children, adolescents and adults.
作者信息
Hübers M, Geisler C, Plachta-Danielzik S, Müller M J
机构信息
Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Kiel, Germany.
Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany.
出版信息
Nutr Diabetes. 2017 May 8;7(5):e267. doi: 10.1038/nutd.2017.20.
OBJECTIVES
To determine age-related associations between fat mass (FM), regional fat depots and cardiometabolic traits in normal- and overweight children, adolescents and adults.
METHODS
Detailed body composition (regional subcutaneous and visceral adipose tissue; SAT, VAT) by whole-body magnetic resonance imaging (MRI), FM and fat-free mass by air-displacement plethysmography, systolic and diastolic blood pressure (SBP, DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL), plasma glucose and plasma insulin were measured in 433 subjects (BMI: 23.6 (21.0-27.7); 151 children and adolescents, aged 6-18 years, 150 young adults, aged 18-30 years and 132 adults, aged 30-60 years). Data were derived from pooled data of the 'Reference Center for Body Composition' in Kiel, Germany. Insulin resistance was determined by the homeostatic model assessment of insulin resistance (HOMA-IR). Partial correlations and multivariate linear regression analyses were used to evaluate the associations between body composition and cardiometabolic traits. A descriptive approach was used to demonstrate age-dependent differences in associations between body fat depots and insulin resistance, independent of BMI.
RESULTS
FM, SAT, and VAT increased from childhood to adulthood with low VAT in children and adolescents. When compared to children, TG was higher in adults. HDL and DBP did not differ between age groups. Insulin resistance was highest in male adolescents and female young adults. Associations between body fat depots and cardiometabolic traits were seen after puberty with no associations in pre- and intrapubertal children. When compared to FM, SAT and VAT had the strongest association with insulin resistance in adults. This association was independent of BMI.
CONCLUSIONS
Associations between individual body fat depots and most cardiometabolic traits became evident after puberty only. The strongest associations were observed between insulin resistance and abdominal fat in adults. The impact of VAT was independent of BMI.
目的
确定正常体重和超重儿童、青少年及成年人的脂肪量（FM）、局部脂肪储存与心脏代谢特征之间的年龄相关性。
方法
对433名受试者进行了详细的身体成分测量（局部皮下和内脏脂肪组织；SAT、VAT），采用全身磁共振成像（MRI）技术，通过空气置换体积描记法测量FM和去脂体重，测量收缩压和舒张压（SBP、DBP）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、血浆葡萄糖和血浆胰岛素。受试者BMI为23.6（21.0 - 27.7）；其中151名儿童和青少年，年龄6 - 18岁，150名青年成年人，年龄18 - 30岁，132名成年人，年龄30 - 60岁。数据来源于德国基尔“身体成分参考中心”的汇总数据。采用稳态模型评估胰岛素抵抗（HOMA - IR）来确定胰岛素抵抗。使用偏相关和多元线性回归分析来评估身体成分与心脏代谢特征之间的关联。采用描述性方法来证明身体脂肪储存与胰岛素抵抗之间的关联存在年龄依赖性差异，且不受BMI影响。
结果
从儿童期到成年期，FM、SAT和VAT均增加，儿童和青少年的VAT较低。与儿童相比，成年人的TG更高。HDL和DBP在各年龄组之间无差异。男性青少年和女性青年成年人的胰岛素抵抗最高。青春期后可见身体脂肪储存与心脏代谢特征之间的关联，青春期前及青春期内儿童无此关联。与FM相比，成年人中SAT和VAT与胰岛素抵抗的关联最强。这种关联独立于BMI。
结论
仅在青春期后，个体身体脂肪储存与大多数心脏代谢特征之间的关联才变得明显。在成年人中，胰岛素抵抗与腹部脂肪之间的关联最为显著。VAT的影响独立于BMI。
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