Xiao Qin, Zhang Shi-Cui, Zhao Bo-Sheng
Department of Marine Biology, Ocean University of China, Qingdao 266003, China.
Huan Jing Ke Xue. 2007 Nov;28(11):2580-5.
Acute and sub-acute toxicities of nonylphenol (NP) on fish were investigated with adult rosy barb (Puntius conchonius). The acute toxicity of NP to adult rosy barb was determined in semi-static bioassays. Median lethal concentration (LC50) value of NP was (1.72 +/- 0.06) micromol/L for 96 h exposure. The effects of sub-toxicity of NP (0.17, 0.34 and 0.68 micromol/L) on the adult rosy barb were studied after 21 d exposure. It showed that testis somatic index (TSI) and ovary somatic index (OSI) were reduced significantly by NP in a dose-dependent manner. The histopathological examination showed that the gland structures were impaired by NP as evidenced by hypertrophied Sertoli cells, a loss of germinal cells in testis, retardation of eggs development and increase in atresia in the follicles of ovary. These suggest that NP exerts adverse effects on the testis and the ovary, and disturbs the development of sperm and eggs. In addition, due to rosy barb high sensitivity to NP, it is also possible to apply rosy barb as a potential fish model to the toxicity of NP.
用成年玫瑰无须魮（Puntius conchonius）研究了壬基酚（NP）对鱼类的急性和亚急性毒性。通过半静态生物测定法测定了NP对成年玫瑰无须魮的急性毒性。暴露96小时后，NP的半数致死浓度（LC50）值为（1.72±0.06）微摩尔/升。在暴露21天后，研究了NP亚毒性（0.17、0.34和0.68微摩尔/升）对成年玫瑰无须魮的影响。结果表明，NP以剂量依赖的方式显著降低了睾丸体细胞指数（TSI）和卵巢体细胞指数（OSI）。组织病理学检查表明，NP损害了腺体结构，表现为支持细胞肥大、睾丸生殖细胞丢失、卵子发育迟缓以及卵巢卵泡闭锁增加。这些表明NP对睾丸和卵巢产生不利影响，并干扰精子和卵子的发育。此外，由于玫瑰无须魮对NP高度敏感，也有可能将玫瑰无须魮作为NP毒性的潜在鱼类模型。
