Department of Marine Biology, Ocean University of China, Qingdao, PR China.
Toxicol Mech Methods. 2008 Jan;18(8):627-33. doi: 10.1080/15376510701623540.
ABSTRACT This study was undertaken to examine the histopathological effects of CCl(4) on rosy barbs and amphioxus with an aim to compare the homology between rosy barb liver and amphioxus digestive caecum. It was found that the 96 h LC(50) values were 23.9 +/- 4 mg/L and 18.9 +/- 2 mg/L for rosy barbs and amphioxus, respectively. Histological examinations showed that exposure to sublethal CCl(4) caused damage to the liver, kidney, and gill in rosy barb, and to the digestive caecum and gill in amphioxus. It is clear that both rosy barb liver and amphioxus digestive caecum were the prominent target organs of CCl(4), suggesting that the digestive caecum in amphioxus is homologous to the liver in rosy barb at least in respect to toxic damages of CCl(4).
摘要 本研究旨在探讨 CCl(4) 对玫瑰鲫和文昌鱼的组织病理学影响，旨在比较玫瑰鲫肝脏和文昌鱼消化盲囊之间的同源性。结果表明，玫瑰鲫和文昌鱼的 96 h LC(50) 值分别为 23.9 +/- 4 mg/L 和 18.9 +/- 2 mg/L。组织学检查显示，亚致死浓度的 CCl(4) 暴露导致玫瑰鲫的肝脏、肾脏和鳃受到损伤，而文昌鱼的消化盲囊和鳃也受到损伤。显然，玫瑰鲫肝脏和文昌鱼消化盲囊都是 CCl(4)的显著靶器官，这表明文昌鱼的消化盲囊至少在 CCl(4 的毒性损伤方面与玫瑰鲫的肝脏同源。
