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Role of insulin-like growth factor 1 and phosphoinositide 3-kinase in a setting of heart disease.

作者信息

McMullen Julie R

机构信息

Baker Heart Research Institute, Melbourne, Victoria, Australia.

出版信息

Clin Exp Pharmacol Physiol. 2008 Mar;35(3):349-54. doi: 10.1111/j.1440-1681.2007.04873.x.

DOI:10.1111/j.1440-1681.2007.04873.x
PMID:18290876
Abstract
  1. The insulin-like growth factor 1 (IGF1)-phosphoinositide 3-kinase (PI3-K) pathway is a critical regulator of cell and organ growth. 2. In the heart, the IGF1-PI3-K pathway induces physiological heart growth with preserved or enhanced cardiac function. 3. The present review specifically discusses the role of the IGF1-PI3-K pathway in the setting of heart disease. 4. Genetic mouse models have highlighted the beneficial effects of the IGF1-PI3-K pathway in the heart in a setting of disease. These include maintenance of contractile function, antifibrotic and anti-apoptotic actions, inhibition of signalling transducers activated in disease settings and regeneration.
摘要

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