蒿甲醚-本芴醇治疗方案在儿科临床实践中的应用:来自肯尼亚的早期经验。

Translation of artemether-lumefantrine treatment policy into paediatric clinical practice: an early experience from Kenya.

作者信息

Zurovac D, Njogu J, Akhwale W, Hamer D H, Snow R W

机构信息

Malaria Public Health and Epidemiology Group, KEMRI/Wellcome Trust Research Programme, Nairobi, Kenya.

出版信息

Trop Med Int Health. 2008 Jan;13(1):99-107. doi: 10.1111/j.1365-3156.2007.01980.x.

Abstract

OBJECTIVE

To describe the quality of outpatient paediatric malaria case-management approximately 4-6 months after artemether-lumefantrine (AL) replaced sulfadoxine-pyrimethamine (SP) as the nationally recommended first-line therapy in Kenya.

METHODS

Cross-sectional survey at all government facilities in four Kenyan districts. Main outcome measures were health facility and health worker readiness to implement AL policy; quality of antimalarial prescribing, counselling and drug dispensing in comparison with national guidelines; and factors influencing AL prescribing for treatment of uncomplicated malaria in under-fives.

RESULTS

We evaluated 193 facilities, 227 health workers and 1533 sick-child consultations. Health facility and health worker readiness was variable: 89% of facilities stocked AL, 55% of health workers had access to guidelines, 46% received in-service training on AL and only 1% of facilities had AL wall charts. Of 940 children who needed AL treatment, AL was prescribed for 26%, amodiaquine for 39%, SP for 4%, various other antimalarials for 8% and 23% of children left the facility without any antimalarial prescribed. When AL was prescribed, 92% of children were prescribed correct weight-specific dose. AL dispensing and counselling tasks were variably performed. Higher health worker's cadre, in-service training including AL use, positive malaria test, main complaint of fever and high temperature were associated with better prescribing.

CONCLUSIONS

Changes in clinical practices at the point of care might take longer than anticipated. Delivery of successful interventions and their scaling up to increase coverage are important during this process; however, this should be accompanied by rigorous research evaluations, corrective actions on existing interventions and testing cost-effectiveness of novel interventions capable of improving and maintaining health worker performance and health systems to deliver artemisinin-based combination therapy in Africa.

摘要

目的

描述在肯尼亚蒿甲醚-本芴醇(AL)取代磺胺多辛-乙胺嘧啶(SP)成为国家推荐的一线治疗药物约4 - 6个月后,儿科门诊疟疾病例管理的质量。

方法

对肯尼亚四个地区所有政府医疗机构进行横断面调查。主要观察指标包括医疗机构和卫生工作者对实施AL政策的准备情况;与国家指南相比,抗疟药物处方、咨询和配药的质量;以及影响五岁以下儿童单纯性疟疾治疗中AL处方的因素。

结果

我们评估了193家医疗机构、227名卫生工作者和1533例患病儿童的会诊情况。医疗机构和卫生工作者的准备情况各不相同:89%的医疗机构储备了AL,55%的卫生工作者可获取指南,46%接受了关于AL的在职培训,只有1%的医疗机构有AL挂图。在940名需要接受AL治疗的儿童中,26%的儿童被开具了AL,39%的儿童被开具了阿莫地喹,4%的儿童被开具了SP,8%的儿童被开具了其他各种抗疟药物,23%的儿童未被开具任何抗疟药物就离开了医疗机构。当开具AL时,92%的儿童被开具了正确的按体重计算的剂量。AL的配药和咨询任务执行情况各不相同。卫生工作者的级别较高、接受包括AL使用在内的在职培训、疟疾检测呈阳性、主要症状为发热以及体温较高与更好的处方开具相关。

结论

医疗现场的临床实践变化可能比预期的时间更长。在此过程中,成功干预措施的实施及其扩大覆盖范围很重要;然而,这应伴随着严格的研究评估、对现有干预措施的纠正行动以及对能够改善和维持卫生工作者绩效及卫生系统以在非洲提供青蒿素联合疗法的新干预措施的成本效益测试。

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