Faraut Thomas
Laboratoire de Génétique Cellulaire, UMR 444 INRA/ENVT, INRA Toulouse, BP 52627, , 31326, Castanet Tolosan Cedex, France.
Chromosome Res. 2008;16(1):5-16. doi: 10.1007/s10577-007-1208-0.
The evolution of karyotypes has been the subject of intensive study since the middle of the 20th century. This was motivated by the observation that the karyotypes of related species showed remarkable conservation. The recent emergence of whole-genome sequencing projects gives the opportunity to complement the cytogenetic approaches by addressing the conservation of karyotypes using chromosome sequence comparison. In this short review we present a description of recent advances in computational biology methods dedicated to the study of chromosome evolution and more specifically ancestral karyotype reconstruction in an attempt to provide an integrated overview of both cytogenetic and computational approaches.
自20世纪中叶以来，核型的进化一直是深入研究的主题。这是由于观察到相关物种的核型表现出显著的保守性。全基因组测序项目的近期出现，为通过染色体序列比较来研究核型的保守性，从而补充细胞遗传学方法提供了机会。在这篇简短的综述中，我们描述了致力于染色体进化研究，特别是祖先核型重建的计算生物学方法的最新进展，试图对细胞遗传学和计算方法进行综合概述。
