Beusterien K M, Davis E A, Flood R, Howard K, Jordan J
Oxford Outcomes, 7272 Wisconsin Avenue, Bethesda, MD 20814, USA.
AIDS Care. 2008 Feb;20(2):244-52. doi: 10.1080/09540120701487666.
Research on HIV medication adherence has relied mainly on quantitative methods. The objective of this study was to explore factors associated with adherence from the HIV-infected patient's perspective. Six focus groups were convened with treatment-experienced HIV-positive individuals. The discussions focused on issues that make it easy or difficult to adhere to HIV regimens. Thirty-five patients participated in the focus groups, which were conducted in Washington, D.C., and Los Angeles. The mean age was 48; 66% were male; 63% were black; and 40% contracted HIV through heterosexual contact. Six major themes emerged from the data that influenced adherence to medication: regimen complexity/medication features (including number of pills), lifestyle fit, emotional impacts (including worry, anger, stress and anxiety), side effects, medication effectiveness, and communication (including information from friends, physicians, and published sources). The data informed a conceptual framework, illustrating the possible interactions among these themes that can potentially be used by clinicians when discussing HIV treatment options with patients. This is potentially one of the first focus group studies concentrating on HIV medication adherence. The findings highlight specific factors that should be considered when trying to improve adherence and may be helpful in clinical decision-making.
关于艾滋病病毒药物依从性的研究主要依赖于定量方法。本研究的目的是从感染艾滋病病毒患者的角度探讨与依从性相关的因素。我们召集了六个焦点小组，参与人员为有治疗经验的艾滋病病毒呈阳性个体。讨论聚焦于使艾滋病病毒治疗方案的坚持变得容易或困难的问题。35名患者参与了在华盛顿特区和洛杉矶进行的焦点小组讨论。平均年龄为48岁；66%为男性；63%为黑人；40%通过异性接触感染艾滋病病毒。数据中出现了影响药物依从性的六个主要主题：治疗方案复杂性/药物特性（包括药片数量）、生活方式适配性、情绪影响（包括担忧、愤怒、压力和焦虑）、副作用、药物疗效以及沟通（包括来自朋友、医生和已发表资料的信息）。这些数据形成了一个概念框架，阐明了这些主题之间可能的相互作用，临床医生在与患者讨论艾滋病病毒治疗方案时可能会用到。这可能是首批专注于艾滋病病毒药物依从性的焦点小组研究之一。研究结果突出了在试图提高依从性时应考虑的具体因素，可能有助于临床决策。
