抗逆转录病毒药物相关不良反应在影响HIV感染者依从性方面的作用：一项系统评价与定性元综合分析
The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis.
作者信息
Li Haochu, Marley Gifty, Ma Wei, Wei Chongyi, Lackey Mellanye, Ma Qingyan, Renaud Françoise, Vitoria Marco, Beanland Rachel, Doherty Meg, Tucker Joseph D
机构信息
School of Public Health, Shandong University, Jinan, China.
UNC Project-China, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
AIDS Behav. 2017 Feb;21(2):341-351. doi: 10.1007/s10461-016-1545-0.
Abstract
Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.
摘要
对抗逆转录病毒药物（ARVs）的依从性差仍然是实现其临床和公共卫生效益的主要障碍。我们进行了一项系统综述和定性元分析，以评估ARV药物不良反应如何影响ARV依从性。共识别出39篇文章，其中33篇报告ARV药物不良反应会降低依从性，6项研究未发现有影响。与其他药物不良反应相比，视觉上明显的药物不良反应和心理不良反应更有可能导致不依从。6项研究报告了一系列与含依非韦伦（EFV）方案相关的不良反应，这些不良反应导致依从性下降。在开始治疗前告知HIV感染者ARV药物不良反应、提供应对机制咨询以及让他们体验ARV对健康的有效性，可能会提高ARV依从性。
相似文献
1
The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis.抗逆转录病毒药物相关不良反应在影响HIV感染者依从性方面的作用：一项系统评价与定性元综合分析
AIDS Behav. 2017 Feb;21(2):341-351. doi: 10.1007/s10461-016-1545-0.
2
A combination drug of abacavir-lamivudine-zidovudine (Trizivir) for treating HIV infection and AIDS.一种用于治疗艾滋病毒感染和艾滋病的阿巴卡韦-拉米夫定-齐多夫定复方药物（三协唯）。
Cochrane Database Syst Rev. 2009 Jul 8(3):CD005481. doi: 10.1002/14651858.CD005481.pub2.
3
Comparative efficacy and safety of first-line antiretroviral therapy for the treatment of HIV infection: a systematic review and network meta-analysis.一线抗逆转录病毒疗法治疗 HIV 感染的疗效和安全性比较：系统评价和网络荟萃分析。
Lancet HIV. 2016 Nov;3(11):e510-e520. doi: 10.1016/S2352-3018(16)30091-1. Epub 2016 Sep 6.
4
Therapeutic drug monitoring of antiretrovirals for people with HIV.对感染艾滋病毒者的抗逆转录病毒药物进行治疗药物监测。
Cochrane Database Syst Rev. 2009 Jul 8(3):CD007268. doi: 10.1002/14651858.CD007268.pub2.
5
Choice of initial antiretroviral drugs and treatment outcomes among HIV-infected patients in sub-Saharan Africa: systematic review and meta-analysis of observational studies.撒哈拉以南非洲地区 HIV 感染患者初始抗逆转录病毒药物的选择和治疗结局：系统评价和观察性研究的荟萃分析。
Syst Rev. 2017 Aug 25;6(1):173. doi: 10.1186/s13643-017-0567-7.
6
Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure.职业性HIV暴露后的抗逆转录病毒暴露后预防（PEP）。
Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD002835. doi: 10.1002/14651858.CD002835.pub3.
7
Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: a systematic literature review and meta-analysis.门诊就诊频率和药物领取对抗逆转录病毒治疗结果的影响：一项系统文献综述和荟萃分析
J Int AIDS Soc. 2017 Jul 21;20(Suppl 4):21647. doi: 10.7448/IAS.20.5.21647.
8
Integrase inhibitors versus efavirenz combination antiretroviral therapies for TB/HIV coinfection: a meta-analysis of randomized controlled trials.整合酶抑制剂与依非韦伦联合抗逆转录病毒疗法治疗结核/艾滋病毒合并感染：随机对照试验的荟萃分析。
AIDS Res Ther. 2021 May 1;18(1):25. doi: 10.1186/s12981-021-00348-w.
9
Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.用于降低人类免疫缺陷病毒感染母婴传播风险的抗逆转录病毒药物。
Cochrane Database Syst Rev. 2007 Jan 24(1):CD003510. doi: 10.1002/14651858.CD003510.pub2.
10
Structured treatment interruptions (STI) in chronic unsuppressed HIV infection in adults.成人慢性未抑制的HIV感染中的结构化治疗中断（STI）
Cochrane Database Syst Rev. 2006 Jul 19;2006(3):CD006148. doi: 10.1002/14651858.CD006148.
引用本文的文献
1
A case of multiple ART intolerance responds to Albuvirtide and Dolutegravir: Case report and literature review.一例多重抗逆转录病毒治疗不耐受患者对阿巴卡韦和多替拉韦有反应：病例报告及文献综述
Heliyon. 2024 Mar 12;10(6):e27219. doi: 10.1016/j.heliyon.2024.e27219. eCollection 2024 Mar 30.
2
Impacts of ainuovirine-based and efavirenz-based antiretroviral therapies on the lipid profile of HIV/AIDS patients in southern China: a real-world study.基于阿依努韦林和依非韦伦的抗逆转录病毒疗法对中国南方HIV/AIDS患者血脂谱的影响：一项真实世界研究。
Front Med (Lausanne). 2024 Jan 8;10:1277059. doi: 10.3389/fmed.2023.1277059. eCollection 2023.
3
Barriers and facilitators to adherence for antiretroviral therapy: the perspectives of patients from a wellness center in the Mpumalanga Province, South Africa.抗逆转录病毒疗法依从性的障碍和促进因素：来自南非姆普马兰加省一个健康中心的患者观点。
Afr Health Sci. 2022 Sep;22(3):455-462. doi: 10.4314/ahs.v22i3.49.
4
Reporting and recording of adverse drug reactions of highly active antiretroviral therapy by HIV infected patients and healthcare professionals respectively in the Ethekwini Metropolitan of Kwa-Zulu Natal, South Africa: a cross-sectional and retrospective comparative study.南非夸祖鲁-纳塔尔省埃滕哈赫温大都市分别由 HIV 感染者和医护人员报告和记录高效抗逆转录病毒疗法的药物不良反应：一项横断面和回顾性比较研究。
Pan Afr Med J. 2022 Jul 20;42:218. doi: 10.11604/pamj.2022.42.218.32239. eCollection 2022.
5
Factors influencing treatment adherence in hypertension and HIV management in South Africa: A comparative literature review.影响南非高血压和艾滋病管理治疗依从性的因素：一项比较文献综述。
S Afr Fam Pract (2004). 2022 Jun 29;64(1):e1-e10. doi: 10.4102/safp.v64i1.5434.
6
Health-Related Quality of Life and Coping Strategies in a Cohort Study of Highly Active Antiretroviral Therapy Naïve Patients Adherence.一项针对高效抗逆转录病毒治疗初治患者依从性的队列研究中的健康相关生活质量和应对策略。
Int J Clin Pract. 2022 Feb 9;2022:8341638. doi: 10.1155/2022/8341638. eCollection 2022.
7
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol.艾滋病毒/艾滋病患者中抗逆转录病毒药物的性别差异和不良事件：系统评价和荟萃分析方案。
BMJ Open. 2022 Feb 24;12(2):e057094. doi: 10.1136/bmjopen-2021-057094.
8
Body image and antiretroviral therapy adherence among people living with HIV: a protocol for a systematic review and meta-analysis.HIV 感染者的身体意象和抗逆转录病毒治疗依从性：系统评价和荟萃分析方案。
BMJ Open. 2021 Jul 7;11(7):e045700. doi: 10.1136/bmjopen-2020-045700.
9
Incidence and predictors of Adverse Drug Reaction (ADR) among adult HIV positive patients on anti-retroviral treatment in Arba Minch town public health facilities, southern Ethiopia: A retrospective cohort study, 2020.在埃塞俄比亚南部阿尔巴明奇镇的公共卫生机构中，接受抗逆转录病毒治疗的成年艾滋病毒阳性患者中不良反应（ADR）的发生率和预测因素：一项回顾性队列研究，2020 年。
PLoS One. 2021 May 27;16(5):e0251763. doi: 10.1371/journal.pone.0251763. eCollection 2021.
10
A mega-aggregation framework synthesis of the barriers and facilitators to linkage, adherence to ART and retention in care among people living with HIV.一项大型综合框架研究，探讨了艾滋病毒感染者在接受抗逆转录病毒治疗（ART）方面的衔接、坚持治疗和保持治疗关系的障碍和促进因素。
Syst Rev. 2021 Feb 11;10(1):54. doi: 10.1186/s13643-021-01582-z.
本文引用的文献
1
Using qualitative evidence in decision making for health and social interventions: an approach to assess confidence in findings from qualitative evidence syntheses (GRADE-CERQual).在卫生和社会干预决策中使用定性证据：一种评估定性证据综合结果可信度的方法（GRADE-CERQual）
PLoS Med. 2015 Oct 27;12(10):e1001895. doi: 10.1371/journal.pmed.1001895. eCollection 2015 Oct.
2
Placebo Effects in Medicine.医学中的安慰剂效应。
N Engl J Med. 2015 Jul 2;373(1):8-9. doi: 10.1056/NEJMp1504023.
3
Efavirenz-Based Regimens in Antiretroviral-Naive HIV-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.初治HIV感染患者中基于依非韦伦的治疗方案：随机对照试验的系统评价和荟萃分析
PLoS One. 2015 May 1;10(5):e0124279. doi: 10.1371/journal.pone.0124279. eCollection 2015.
4
Comparative Safety and Neuropsychiatric Adverse Events Associated With Efavirenz Use in First-Line Antiretroviral Therapy: A Systematic Review and Meta-Analysis of Randomized Trials.一线抗逆转录病毒治疗中使用依非韦伦的比较安全性及神经精神不良事件：一项随机试验的系统评价和荟萃分析
J Acquir Immune Defic Syndr. 2015 Aug 1;69(4):422-9. doi: 10.1097/QAI.0000000000000606.
5
Factors related to antiretroviral therapy adherence in children and adolescents with HIV/AIDS in Cuba.古巴感染艾滋病毒/艾滋病的儿童和青少年中与抗逆转录病毒疗法依从性相关的因素。
MEDICC Rev. 2015 Jan;17(1):35-40. doi: 10.37757/MR2015.V17.N1.8.
6
Determinants of Antiretroviral Therapy Adherence among Women in Southern Malawi: Healthcare Providers' Perspectives.马拉维南部女性抗逆转录病毒治疗依从性的决定因素：医疗服务提供者的观点
AIDS Res Treat. 2014;2014:489370. doi: 10.1155/2014/489370. Epub 2014 Dec 28.
7
Barriers and facilitators to paediatric adherence to antiretroviral therapy in rural South Africa: a multi-stakeholder perspective.南非农村地区儿童抗逆转录病毒治疗依从性的障碍与促进因素：多利益相关方视角
AIDS Care. 2015;27(3):315-21. doi: 10.1080/09540121.2014.967658. Epub 2014 Oct 30.
8
Qualitative analysis of barriers and facilitators encountered by HIV patients in an ART adherence programme.HIV 患者在接受抗逆转录病毒治疗（ART）过程中遇到的障碍和促进因素的定性分析。
Int J Clin Pharm. 2014 Aug;36(4):716-24. doi: 10.1007/s11096-014-9930-0. Epub 2014 Jun 10.
9
Barriers and facilitators of adherence to antiretroviral drug therapy and retention in care among adult HIV-positive patients: a qualitative study from Ethiopia.成人HIV阳性患者坚持抗逆转录病毒药物治疗及持续接受治疗的障碍与促进因素：来自埃塞俄比亚的一项定性研究
PLoS One. 2014 May 14;9(5):e97353. doi: 10.1371/journal.pone.0097353. eCollection 2014.
10
Medication adherence in HIV-positive patients with diabetes or hypertension: a focus group study.HIV 阳性合并糖尿病或高血压患者的用药依从性：一项焦点小组研究。
BMC Health Serv Res. 2013 Nov 25;13:488. doi: 10.1186/1472-6963-13-488.
Zotero 插件