拉坦前列素与多佐胺/噻吗洛尔固定复方治疗2个月和6个月后24小时眼压降低效果的比较。

Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment.

作者信息

Konstas Anastasios G P, Kozobolis Vassilios P, Tsironi Sevasti, Makridaki Irene, Efremova Rallitsa, Stewart William C

机构信息

Glaucoma Unit, First University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.

出版信息

Ophthalmology. 2008 Jan;115(1):99-103. doi: 10.1016/j.ophtha.2007.03.007.

PURPOSE

To evaluate the 24-hour intraocular pressure (IOP)-lowering effect of latanoprost and the dorzolamide/timolol fixed combination (DTFC) after 2 and 6 months of treatment.

DESIGN

Randomized, prospective, crossover comparison.

PARTICIPANTS

Thirty-nine patients had primary open-angle glaucoma, and 14 patients had ocular hypertension.

METHODS

After a 6-week washout period, patients were randomized to either 6 months of treatment with the DTFC twice daily or latanoprost every evening and then crossed over to the opposite treatment for an additional 6 months.

MAIN OUTCOME MEASURE

Mean 24-hour IOP after 2 and 6 months of treatment.

RESULTS

Fifty-three patients had an average 24-hour baseline IOP of 25.2+/-2.3 mmHg. After 6 months of treatment, 24-hour IOPs were 18.1+/-1.9 mmHg for the DTFC and 18.3+/-1.9 mmHg for latanoprost. Compared with 2 months of therapy, at 6 months the DTFC showed no significant change in mean 24-hour IOP, whereas latanoprost demonstrated a reduction of 0.3 mmHg (P = 0.01). The DTFC had more burning (P<0.001) and bitter taste (P = 0.01), whereas the latanoprost had more hypertrichosis (P = 0.02).

CONCLUSIONS

After 6 months of therapy, the DTFC and latanoprost have clinically similar 24-hour IOP-lowering efficacies.

目的

评估拉坦前列素和多佐胺/噻吗洛尔固定复方制剂（DTFC）治疗2个月和6个月后的24小时眼压（IOP）降低效果。

设计

随机、前瞻性、交叉比较。

参与者

39例原发性开角型青光眼患者和14例高眼压症患者。

方法

经过6周的洗脱期后，患者被随机分为两组，一组每天两次使用DTFC治疗6个月，另一组每晚使用拉坦前列素治疗6个月，然后交叉接受相反的治疗再持续6个月。

主要观察指标

治疗2个月和6个月后的平均24小时眼压。

结果

53例患者的24小时基线眼压平均为25.2±2.3 mmHg。治疗6个月后，DTFC组的24小时眼压为18.1±1.9 mmHg，拉坦前列素组为18.3±1.9 mmHg。与治疗2个月相比，治疗6个月时DTFC组的平均24小时眼压无显著变化，而拉坦前列素组降低了0.3 mmHg（P = 0.01）。DTFC组的烧灼感（P<0.001）和苦味（P = 0.01）更明显，而拉坦前列素组的多毛症（P = 0.02）更明显。

结论

治疗6个月后，DTFC和拉坦前列素在临床上具有相似的24小时眼压降低疗效。