极光激酶作为一种抗癌靶点。

Aurora kinases as an anti-cancer target.

出版信息

Cancer Lett. 2008 Apr 8;262(1):1-9. doi: 10.1016/j.canlet.2008.01.005. Epub 2008 Feb 21.

DOI:10.1016/j.canlet.2008.01.005

Abstract

The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases.

摘要

极光激酶家族在有丝分裂过程中对染色体的排列、分离和胞质分裂起着重要作用。最近的研究发现，极光激酶在多种人类实体瘤和血液恶性肿瘤中的表达异常，表明它们在肿瘤发生中起作用。这篇综述强调了极光激酶在有丝分裂调控中的作用，并提出了将这些激酶作为抗癌靶点的基本原理。我还回顾了最近开发的极光激酶抑制剂。